Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges
文献类型：期刊论文
| 作者 | Wang, Tong1; Yang, Lintong1; Wang, Guangfei1; Han, Lei1; Chen, Kaili1; Liu, Ping1; Xu, Shumin1; Li, Dongsheng3; Xie, Zeping2; Mo, Xiumei3 |
| 刊名 | JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
 |
| 出版日期 | 2021 |
| 卷号 | 36期号:1页码:44-58 |
| 关键词 | tilapia skin collagen collagen sponge biocompatibility wound healing hemostatic properties |
| ISSN号 | 0883-9115 |
| DOI | 10.1177/0883911520981705 |
| 通讯作者 | Zhang, Shumin(shumin_zhang@outlook.com) ; Gao, Yonglin(gylbill@163.com) |
| 英文摘要 | Dialyzed tilapia skin collagen sponge (DTSCS) and self-assembled tilapia skin collagen sponge (STSCS) were prepared by freeze-drying. The raw components used in the fabrication of DTSCS and STSCS were separated and purified from tilapia fish skin. It is anticipated that these collagen sponges could be developed into medical dressings for hemostasis and wound healing. The aim of the present research was to explore the possibility of DTSCS and STSCS as medical dressings and compare their differences by scanning electron microscopy (SEM), water absorption measurement, differential scanning calorimetry (DSC), measurement of porosity, cytotoxicity, hemolysis, in vivo biocompatibility, and evaluation of hemostatic performance and wound healing. The results indicate that DTSCS and STSCS are suitable materials for use in medical applications with a loose and porous structure, high water absorption, high porosity, and high thermal stability. The materials also displayed good biocompatibility, including excellent blood compatibility, a lack of cytotoxicity, with no apparent rejection following implantation. STSCS exhibited rapid hemostasis and promoted healing, with slightly greater efficacy than DTSCS. The hemostatic properties and promotion of healing in DTSCS was similar to that of commercial bovine collagen sponge. Therefore, DTSCS and STSCS both represented excellent potential candidate materials for use as hemostatic agents and wound dressings. |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Materials Science ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000605949700004 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/26155]  |
| 专题 | 烟台海岸带研究所_中科院烟台海岸带研究所知识产出 中国科学院烟台海岸带研究所 |
| 通讯作者 | Zhang, Shumin; Gao, Yonglin |
| 作者单位 | 1.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China 2.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 3.Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 5.Yantai Testing Ctr Food & Drug, Yantai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Tong,Yang, Lintong,Wang, Guangfei,et al. Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2021,36(1):44-58. |
| APA | Wang, Tong.,Yang, Lintong.,Wang, Guangfei.,Han, Lei.,Chen, Kaili.,...&Gao, Yonglin.(2021).Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges.JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,36(1),44-58. |
| MLA | Wang, Tong,et al."Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges".JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 36.1(2021):44-58. |
入库方式： OAI收割
来源：烟台海岸带研究所
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