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  4. 海岸带生物学与生物资源利用重点实验室
A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells

文献类型：期刊论文

作者Pu, Yang1,2; Wei, Mengjiao2; Witkowski, Andrzej4; Krzywda, Marta4; Wang, Yinchu3; Li, Wenjun3
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2020-12-10
卷号533期号:3页码:573-579
关键词Biofunctional biosilica C-phycocyanin Phycocyanobilin Enhanced photodynamic effect Nanocarriers
ISSN号0006-291X
DOI10.1016/j.bbrc.2020.09.049
通讯作者Pu, Yang(ypu@ldu.edu.cn) ; Li, Wenjun(wjli@yic.ac.cn)
英文摘要Intricate mesoporous biosilica has many biomedical applications as a nanocarrier. However, its potential use in photodynamic therapy (PDT) has received little attention. This work reports the first fabrication of bio-engineered materials by covalently conjugating C-phycocyanin (C-PC), a natural photosensitizer, to biosilica for the PDT of tumor-associated macrophages. The resulting hybrid material showed outstanding photodynamic activity under 620 nm laser irradiation. Furthermore, it enhanced the relatively weak photodynamic effect of C-PC. This study also explored methods of biofunctionalizing biosilica for cancer phototherapy, a new pharmacological application of non-toxic C-PC. (C) 2020 Elsevier Inc. All rights reserved.
WOS关键词APOPTOSIS ; DIATOMS ; PHYCOBILIPROTEINS ; PHYCOBILISOMES ; ANTIOXIDANT ; CYCLE ; DRUG
资助项目National Natural Science Foundation of China[41906109] ; Key Research and Development Program of Yantai[2019XDHZ101] ; Key Research and Development Program of Yantai[2020MSGY084] ; TEAM-NET programme of the Foundation for Polish Science ; European Union under the European Regional Development Fund
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000588268300046
资助机构National Natural Science Foundation of China ; Key Research and Development Program of Yantai ; TEAM-NET programme of the Foundation for Polish Science ; European Union under the European Regional Development Fund
源URL[http://ir.yic.ac.cn/handle/133337/28320]  
专题海岸带生物学与生物资源利用重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者Pu, Yang; Li, Wenjun
作者单位1.Ludong Univ, Bionanotechnol Res Inst, Yantai 264025, Peoples R China
2.Ludong Univ, Sch Agr, Yantai 264025, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
4.Univ Szczecin, Inst Marine & Environm Sci, Szczecin, Poland
推荐引用方式
GB/T 7714		 Pu, Yang,Wei, Mengjiao,Witkowski, Andrzej,et al. A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020,533(3):573-579.
APA Pu, Yang,Wei, Mengjiao,Witkowski, Andrzej,Krzywda, Marta,Wang, Yinchu,&Li, Wenjun.(2020).A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,533(3),573-579.
MLA Pu, Yang,et al."A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533.3(2020):573-579.

入库方式： OAI收割

来源：烟台海岸带研究所

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