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Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP)

文献类型：期刊论文

作者Wang, Xiaoqing1,4; Li, Fei1,2; Liu, Jialin1; Ji, Chenglong1,2,3; Wu, Huifeng1,2,3
刊名ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
出版日期2020-12-01
卷号205页码:9
关键词Triphenyl phosphate (TPP) Multi-omit approach Hepatotoxicity
ISSN号0147-6513
DOI10.1016/j.ecoenv.2020.111126
通讯作者Li, Fei(fli@yic.ac.cn) ; Wu, Huifeng(hfwu@yic.ac.cn)
英文摘要Triphenyl phosphate (TPP) has been found in various environmental media and in biota suggesting widespread human exposure. However, there is still insufficient information on the hepatotoxicity mechanisms of health risk exposed to TPP. In this study, TPP could induce human normal liver cell (L02) apoptosis, injury cell ultrastructure and elevate the levels of reactive oxygen species (ROS). The integrated multi-omit (transcriptomic, proteomic, and metabolomic) analysis was used to further investigate the mechanisms. Transcriptomic analysis revealed that TPP exposure markedly affected cell apoptosis, oncogene activation, REDOX homeostasis, DNA damage and repair. Additionally, proteomic analysis found that the related proteins associated with apoptosis, oxidative stress, metabolism and membrane structure were affected. And metabolomic analysis verified that the related metabolic pathways, such as glycolysis, citrate cycle, oxidative phosphorylation, lipid and protein metabolism, were also significantly disrupted. Based on the multi-omic results, a hypothesized network was constructed to discover the key molecular events in response to TPP and illustrate the mechanism of TPP-induced hepatotoxicity in L02 cells. Therefore, molecular responses could be elucidated at multiple biological levels, and multi-omic analysis could provide scientific tools for exploring potential mechanisms of toxicity and chemical risk assessment.
WOS关键词ORGANOPHOSPHORUS FLAME RETARDANTS ; IN-VITRO ; TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE ; ANTIANDROGENIC ACTIVITY ; DNA-REPAIR ; CELLS ; P53 ; PLASTICIZERS ; NMR ; MITOCHONDRIA
资助项目National Natural Science Foundation of China[21677173] ; National Natural Science Foundation of China[41530642] ; Youth Innovation Promotion Association CAS[2017255]
WOS研究方向Environmental Sciences & Ecology ; Toxicology
语种英语
WOS记录号WOS:000582219300017
资助机构National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS
源URL[http://ir.yic.ac.cn/handle/133337/28419]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_近岸生态与环境实验室
烟台海岸带研究所_支撑部门
通讯作者Li, Fei; Wu, Huifeng
作者单位1.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xiaoqing,Li, Fei,Liu, Jialin,et al. Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP)[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2020,205:9.
APA Wang, Xiaoqing,Li, Fei,Liu, Jialin,Ji, Chenglong,&Wu, Huifeng.(2020).Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP).ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,205,9.
MLA Wang, Xiaoqing,et al."Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP)".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 205(2020):9.

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来源：烟台海岸带研究所

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