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  4. 山东省海岸带环境工程技术研究中心
Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging

文献类型：期刊论文

作者He, Na1; Yu, Lei6; Xu, Minghua5; Huang, Yan3,4; Wang, Xiaoyan3,4; Chen, Lingxin2,3,4; Yue, Shouwei1
刊名JOURNAL OF MATERIALS CHEMISTRY B
出版日期2021-03-21
卷号9期号:11页码:2623-2630
ISSN号2050-750X
DOI10.1039/d0tb02833a
通讯作者Chen, Lingxin(lxchen@yic.ac.cn) ; Yue, Shouwei(shouweiy@sdu.edu.cn)
英文摘要Dietary restriction (DR), as a natural intervention, not only benefits the neuroendocrine system, but also has an antiaging action. Acetylcholinesterase (AChE) is one of the most important bioactive substances and plays a major part in choline changes in the aging process. Thus, we aim to evaluate the effect of DR on AChE in the brains of aging animals. In this study, we synthesize a NIR fluorescent probe BD-AChE for the real-time and in situ monitoring of AChE level changes in living cells and living mice, notably in brains. In situ visualization with BD-AChE verified a decrease in the AchE level in the brains of mice aging models. Evidently, the prepared probe has the excellent capability of measuring AChE variation in the brains of aging mice with DR via NIR fluorescence bioimaging, indicating that long-term DR can effectively affect AChE levels in the brain. The attenuation of AChE level in the brain of aging mice after DR could be helpful in infering the advantageous impact of DR on age-related neurodegenerative disease, as a better treatment alternative in the future.
资助项目National Nature Science Foundation of China[81573393] ; National Nature Science Foundation of China[21804010] ; National Nature Science Foundation of China[21976209] ; National Nature Science Foundation of China[22007005] ; Science and Technology Innovation Development Plan of Yantai of China[2020MSGY113] ; Research Initiation Fund of Binzhou Medical University[BY2019KYQD39] ; Research Initiation Fund of Binzhou Medical University[BY2020KYQD01] ; Taishan Scholar Project Special Funding[ts20190962] ; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization[2018LS014] ; Weifang Science and Technology Development Project[2019GX076]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000632213400003
资助机构National Nature Science Foundation of China ; Science and Technology Innovation Development Plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding ; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization ; Weifang Science and Technology Development Project
源URL[http://ir.yic.ac.cn/handle/133337/27244]  
专题烟台海岸带研究所_山东省海岸带环境工程技术研究中心
烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者Chen, Lingxin; Yue, Shouwei
作者单位1.Shandong Univ, Qilu Hosp, Cheelo Coll Med, Rehabil Ctr, Jinan 250100, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
4.Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
5.Yantai Cent Blood Stn, Yantai 264003, Peoples R China
6.Weifang Univ Sci & Technol, Shandong Peninsula Engn Res Ctr Comprehens Brine, Weifang 262700, Peoples R China
推荐引用方式
GB/T 7714		 He, Na,Yu, Lei,Xu, Minghua,et al. Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2021,9(11):2623-2630.
APA He, Na.,Yu, Lei.,Xu, Minghua.,Huang, Yan.,Wang, Xiaoyan.,...&Yue, Shouwei.(2021).Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging.JOURNAL OF MATERIALS CHEMISTRY B,9(11),2623-2630.
MLA He, Na,et al."Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging".JOURNAL OF MATERIALS CHEMISTRY B 9.11(2021):2623-2630.

入库方式： OAI收割

来源：烟台海岸带研究所

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