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A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models

文献类型：期刊论文

作者He, Na1,2; Wang, Yude1,2; Huang, Yan3; Wang, Xiaoyan3; Chen, Lingxin3,4; Lv, Changjun1,2
刊名SENSORS AND ACTUATORS B-CHEMICAL
出版日期2020-11-01
卷号322页码:8
关键词Fluorescent probe Near-infrared Glutamyl transpeptidase Idiopathic pulmonary fibrosis Fluorescence imaging
DOI10.1016/j.snb.2020.128565
通讯作者Huang, Yan(huangyanpy@163.com) ; Chen, Lingxin(lxchen@yic.ac.cn) ; Lv, Changjun(lucky_lcj@sina.com)
英文摘要Idiopathic pulmonary fibrosis (IPF), whose early diagnosis and effective treatment still remain the focus of clinical studies, is a chronic, irreversible and finally fatal pulmonary disease. Glutamyl transpeptidase (GGT) has a potential relationship with the occurrence and development of IPF. Therefore, explore whether GGT can be applied as a biological indicator for the clinical identification and diagnosis of IPF, sensitive and accurate detection of GGT under physiological conditions is necessary. In this research, a new fluorescent probe Cy-GGT was exhibited for detecting GGT concentrations in pulmonary fibrosis cell and mice models. Cy-GGT was capable of rapidly and selectively detecting GGT in vitro. The probe was successfully applied for visualizing GGT in oxidative stress cell models, pulmonary fibrosis cells and mice models. The results revealed that intracellular GGT increased in the cells and mice models of pulmonary fibrosis. GGT plays a significant part in pulmonary fibrosis, and the GGT level abnormally expressed in the lung tissue may be employed as a potential biological indicator to diagnose IPF lesions. Furthermore, the discovery of the close relationship between IPF and GGT will provide a new idea for effective therapy of IPF in the future.
WOS关键词GLUTATHIONE-S-TRANSFERASE ; GAMMA-GLUTAMYLTRANSPEPTIDASE ; AGGREGATION ; ASSOCIATION ; LIVER
资助项目National Nature Science Foundation of China[81573393] ; National Nature Science Foundation of China[21804010] ; National Nature Science Foundation of China[21976209] ; National Nature Science Foundation of China[81870001] ; science and technology innovation development plan of Yantai of China[2020MSGY113] ; Research Initiation Fund of Binzhou Medical University[BY2019KYQD39] ; Research Initiation Fund of Binzhou Medical University[BY2020KYQD01] ; Taishan Scholar Project Special Funding[ts20190962]
WOS研究方向Chemistry ; Electrochemistry ; Instruments & Instrumentation
语种英语
WOS记录号WOS:000573296500018
资助机构National Nature Science Foundation of China ; science and technology innovation development plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding
源URL[http://ir.yic.ac.cn/handle/133337/28490]  
专题烟台海岸带研究所_山东省海岸带环境工程技术研究中心
烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者Huang, Yan; Chen, Lingxin; Lv, Changjun
作者单位1.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China
2.Binzhou Med Univ, Med Res Ctr, Inst Mol Med, Yantai 264003, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 He, Na,Wang, Yude,Huang, Yan,et al. A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models[J]. SENSORS AND ACTUATORS B-CHEMICAL,2020,322:8.
APA He, Na,Wang, Yude,Huang, Yan,Wang, Xiaoyan,Chen, Lingxin,&Lv, Changjun.(2020).A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models.SENSORS AND ACTUATORS B-CHEMICAL,322,8.
MLA He, Na,et al."A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models".SENSORS AND ACTUATORS B-CHEMICAL 322(2020):8.

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来源：烟台海岸带研究所

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