Bioaccumulation, Biotransformation, and Multicompartmental Toxicokinetic Model of Antibiotics in Sea Cucumber (Apostichopus japonicus)
文献类型：期刊论文
| 作者 | Zhu, Minghua2; Wang, Zhongyu2; Chen, Jingwen2; Xie, Huaijun2; Zhao, Hongxia2; Yuan, Xiutang1,3
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| 出版日期 | 2020-10-20 |
| 卷号 | 54期号:20页码:13175-13185 |
| ISSN号 | 0013-936X |
| DOI | 10.1021/acs.est.0c04421 |
| 通讯作者 | Chen, Jingwen(jwchen@dlut.edu.cn) ; Yuan, Xiutang(xtyuan@yic.ac.cn) |
| 英文摘要 | Extensive application of antibiotics leads to their ubiquitous occurrence in coastal aquatic environments. However, it remains largely unknown whether antibiotics can be bioaccumulated and biotransformed in major mariculture organisms such as sea cucumbers and toxicokinetic models for Echinodermata are lacking. In this study, laboratory exposure experiments on juvenile sea cucumber (Apostichopus japonicus) were performed for seven antibiotics (sulfadiazine, sulfamethoxazole, trimethoprim, enrofloxacin, ofloxacin, clarithromycin, and azithromycin). Field sea cucumber and surrounding seawater samples were also analyzed. Results show that the sea cucumbers tend to accumulate high concentrations of the antibiotics with kinetic bioconcentration factors (BCFs) up to 1719.7 L.kg(-1) for ofloxacin. The BCFs determined in the laboratory agree well with those estimated from the field measurements. Seven biotransformation products (BTPs) of the antibiotics were identified, four of which were not reported previously in aquatic organisms. The BTPs were mainly found in the digestive tract, indicating its high capacity in the biotransformation. A multicompartmental toxicokinetic model based on the principles of passive diffusion was developed, which can successfully predict time-course concentrations of the antibiotics in different compartments of the juvenile sea cucumbers. The findings may offer a scientific basis for assessing health risks and guiding healthy mariculture of sea cucumbers. |
| WOS关键词 | CARP CYPRINUS-CARPIO ; TISSUE DISTRIBUTION ; ORGANIC-CHEMICALS ; COASTAL WATER ; LAIZHOU BAY ; AQUATIC ENVIRONMENT ; HYDROXY METABOLITES ; DERMAL ABSORPTION ; CHINA OCCURRENCE ; HUMAN EXPOSURE |
| 资助项目 | National Key R&D Program of China[2018YFE0110700] ; National Key R&D Program of China[2018YFC1801604] ; National Natural Science Foundation of China[21661142001] ; National Natural Science Foundation of China[41676164] |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:000584422500039 |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/28308]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_近岸生态与环境实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Chen, Jingwen; Yuan, Xiutang |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Dalian Univ Technol, Sch Environm Sci & Technol, Minist Educ, Key Lab Ind Ecol & Environm Engn, Dalian 116024, Peoples R China 3.Minist Ecol & Environm, Natl Marine Environm Monitoring Ctr, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Minghua,Wang, Zhongyu,Chen, Jingwen,et al. Bioaccumulation, Biotransformation, and Multicompartmental Toxicokinetic Model of Antibiotics in Sea Cucumber (Apostichopus japonicus)[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(20):13175-13185. |
| APA | Zhu, Minghua,Wang, Zhongyu,Chen, Jingwen,Xie, Huaijun,Zhao, Hongxia,&Yuan, Xiutang.(2020).Bioaccumulation, Biotransformation, and Multicompartmental Toxicokinetic Model of Antibiotics in Sea Cucumber (Apostichopus japonicus).ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(20),13175-13185. |
| MLA | Zhu, Minghua,et al."Bioaccumulation, Biotransformation, and Multicompartmental Toxicokinetic Model of Antibiotics in Sea Cucumber (Apostichopus japonicus)".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.20(2020):13175-13185. |
入库方式： OAI收割
来源：烟台海岸带研究所
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