Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction
文献类型：期刊论文
| 作者 | Tan, Wenqiang1,2 ; Zhang, Jingjing1,2; Mi, Yingqi1,2,3; Dong, Fang1,2; Li, Qing1,2; Guo, Zhanyong1,2,3
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2020-12-15 |
| 卷号 | 165页码:1765-1772 |
| ISSN号 | 0141-8130 |
| 关键词 | Chitosan Azide-alkyne click reaction Triphenylphosphonium Antifungal activity |
| DOI | 10.1016/j.ijbiomac.2020.10.019 |
| 通讯作者 | Guo, Zhanyong(zhanyongguo@hotmail.com) |
| 英文摘要 | As one of the most promising biopolymers for a variety of potential applications, chitosan has attractedmuch attention because of its unique biological, chemical, and physical properties. The functionalization of chitosan has been adopted to synthesize novel chitosan derivatives with improved water-solubility and excellent biological activities. In this paper, chitosanwas functionalized with a triphenylphosphoniumgroup by means of the copper (I) catalyzed azide-alkyne "click" reaction and has been investigated as potential polymer for agricultural antifungal biomaterial. The influence of chemical modification on the structural characteristics and water-solubility of chitosanwas investigated by FTIR spectroscopy, H-1 NMRspectroscopy, elemental analysis, and UV-vis spectrum. Furthermore, the antifungal property of target chitosan derivative against four plant threatening fungal pathogens was evaluated and in vitro investigation demonstrated that triphenylphosphoniumsalt incorporated chitosan backbone had excellent antifungal property compared with chitosan and intermediate chitosan derivative. Notably, target chitosan derivative displayed relatively strongest antifungal effect with over 80% inhibitory index against Botrytis cinerea at 1.0 mg/mL. The results of a detailed antifungal study indicated that cationic chitosan derivative bearing 1,2,3-triazole and triphenylphosphonium moieties provided a promising platform for preparation of novel cationic antifungal biomaterials in the field of agriculture. (C) 2020 Elsevier B.V. All rights reserved. |
| WOS关键词 | ANTIMICROBIAL ACTIVITY ; QUATERNARY AMMONIUM ; PHOSPHONIUM ; ANTIOXIDANT ; CHEMISTRY |
| 资助项目 | Youth Innovation Promotion Association CAS[2020219] ; Natural Science Foundation of Shandong Province of China[ZR2019BD064] ; National Key Research and Development Program of China[2019YFD0900705] ; Natural Science Foundation of Shandong Province Science and Technology Development Plan[2019GHY112010] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000600773500016 |
| 资助机构 | Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China ; National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan |
| 源URL | [http://ir.yic.ac.cn/handle/133337/26156]  |
| 专题 | 海岸带生物资源高效利用研究与发展中心 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 烟台海岸带研究所_近岸生态与环境实验室 |
| 通讯作者 | Guo, Zhanyong |
| 作者单位 | 1.Chinese Acad Sci, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Wenqiang,Zhang, Jingjing,Mi, Yingqi,et al. Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,165:1765-1772. |
| APA | Tan, Wenqiang,Zhang, Jingjing,Mi, Yingqi,Dong, Fang,Li, Qing,&Guo, Zhanyong.(2020).Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,165,1765-1772. |
| MLA | Tan, Wenqiang,et al."Enhanced antifungal activity of novel cationic chitosan derivative bearing triphenylphosphonium salt via azide-alkyne click reaction".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 165(2020):1765-1772. |
入库方式： OAI收割
来源：烟台海岸带研究所
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