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Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8

文献类型：期刊论文

作者Shi, Xiao-Shan4,5; Song, Yin-Ping3; Meng, Ling-Hong4,5; Yang, Sui-Qun4,5; Wang, Dun-Jia2; Zhou, Xing-Wang2; Ji, Nai-Yun1,3; Wang, Bin-Gui1,4,5; Li, Xiao-Ming1,4,5
刊名ANTIBIOTICS-BASEL
出版日期2021-02-01
卷号10期号:2页码:10
关键词Artemisia argyi endophytic fungus Trichoderma virens carotane sesquiterpenes antibacterial activity
ISSN号2079-6382
DOI10.3390/antibiotics10020213
通讯作者Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Li, Xiao-Ming(lixmqd@qdio.ac.cn)
英文摘要Carotane sesquiterpenes are commonly found in plants but are infrequently reported in the fungal kingdom. Chemical investigation of Trichoderma virens QA-8, an endophytic fungus associated with the inner root tissue of the grown medicinal herb Artemisia argyi H. Lev. and Vaniot, resulted in the isolation and characterization of five new carotane sesquiterpenes trichocarotins I-M (1-5), which have diverse substitution patterns, and seven known related analogues (6-12). The structures of these compounds were established on the basis of a detailed interpretation of their NMR and mass spectroscopic data, and the structures including the relative and absolute configurations of compounds 1-3, 5, 9, and 10 were confirmed by X-ray crystallographic analysis. In the antibacterial assays, all isolates exhibited potent activity against Escherichia coli EMBLC-1, with MIC values ranging from 0.5 to 32 mu g/mL, while 7 beta-hydroxy CAF-603 (7) strongly inhibited Micrococcus luteus QDIO-3 (MIC = 0.5 mu g/mL). Structure-activity relationships of these compounds were discussed. The results from this study demonstrate that the endophytic fungus T. virens QA-8 from the planted medicinal herb A. argyi is a rich source of antibacterial carotane sesquiterpenes, and some of them might be interesting for further study to be developed as novel antibacterial agents.
资助项目National Natural Science Foundation of China[31870328]
WOS研究方向Infectious Diseases ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000622009800001
资助机构National Natural Science Foundation of China
源URL[http://ir.yic.ac.cn/handle/133337/27384]  
专题海岸带生物学与生物资源利用重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
海岸带生物资源高效利用研究与发展中心
通讯作者Wang, Bin-Gui; Li, Xiao-Ming
作者单位1.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Hubei Normal Univ, Coll Chem & Chem Engn, Cihu Rd 11, Huangshi 435002, Hubei, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Xiao-Shan,Song, Yin-Ping,Meng, Ling-Hong,et al. Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8[J]. ANTIBIOTICS-BASEL,2021,10(2):10.
APA Shi, Xiao-Shan.,Song, Yin-Ping.,Meng, Ling-Hong.,Yang, Sui-Qun.,Wang, Dun-Jia.,...&Li, Xiao-Ming.(2021).Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8.ANTIBIOTICS-BASEL,10(2),10.
MLA Shi, Xiao-Shan,et al."Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8".ANTIBIOTICS-BASEL 10.2(2021):10.

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来源：烟台海岸带研究所

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