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  4. 海岸带生物学与生物资源利用重点实验室
Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model

文献类型：期刊论文

作者Li, Wenjun2,4; Lu, Lina3; Liu, Bin1; Qin, Song4
刊名BIOMEDICINE & PHARMACOTHERAPY
出版日期2020-12-01
卷号132页码:9
关键词Thorax irradiation Pulmonary fibrosis Microbiota Phycocyanin
ISSN号0753-3322
DOI10.1016/j.biopha.2020.110826
通讯作者Liu, Bin(binliu0736@126.com) ; Qin, Song(sqin@yic.an.cn)
英文摘要Objective: Radiation pneumonia and fibrosis are major clinical complications of radiotherapy for thoracic tumor patients, and may significantly reduce survival and quality of life. At present, no safe and effective radiation protection measures have been approved for clinical use. Phycocyanin, a protein responsible for photosynthesis from Spirulina, has been shown to have a variety of biological activities and to be beneficial for a variety of diseases, including pulmonary fibrosis. However, the preventive and protective effects of phycocyanin on radiation-induced pulmonary fibrosis have not been studied. Design: X-ray single dose irradiation was used on the chest of mice to prepare a mouse model of pulmonary fibrosis, from which the effect of phycocyanin on pulmonary histopathologic change, pulmonary fibrosis, the microbiota in lung and gut, LPS, TNF-alpha, and IL-6 at different time after irradiation were evaluated. Results: Phycocyanin alleviated the radiation-induced lung injury and reduced the level of inflammatory factors. Thorax irradiation led to the disorder in microbiota of the lung and gut. The variation trend of the diversity of the two tissues was opposite, but that of the microbiota composition was similar. The phycocyanin intervention regulated the composition of the lung and gut microbiota, transformed them into normal state, and reduced the level of LPS, which significantly reduced the abundance of inflammation-related bacteria, and increased the abundance of probiotics that produce short-chain fatty acids. Conclusion: Phycocyanin could regulate the radiation-induced disorder in lung and gut microbiota of mice, and reduce the radiation-induced lung inflammation and fibrosis.
WOS关键词IRRITABLE-BOWEL-SYNDROME ; HELICOBACTER-PYLORI ; C-PHYCOCYANIN ; INFLAMMATION ; EXPRESSION
资助项目National Natural Science Foundation of China[41176144] ; Key Research and Development Program of Yantai[2019XDHZ101] ; Key Research and Development Program of Yantai[2020MSGY084]
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000593704500002
资助机构National Natural Science Foundation of China ; Key Research and Development Program of Yantai
源URL[http://ir.yic.ac.cn/handle/133337/28281]  
专题海岸带生物学与生物资源利用重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者Liu, Bin; Qin, Song
作者单位1.Lanzhou Univ, Sch Stomatol, Lanzhou, Gansu, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
3.Northwest Minzu Univ, Sch Chem Engn, Lanzhou, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China
推荐引用方式
GB/T 7714		 Li, Wenjun,Lu, Lina,Liu, Bin,et al. Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model[J]. BIOMEDICINE & PHARMACOTHERAPY,2020,132:9.
APA Li, Wenjun,Lu, Lina,Liu, Bin,&Qin, Song.(2020).Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model.BIOMEDICINE & PHARMACOTHERAPY,132,9.
MLA Li, Wenjun,et al."Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model".BIOMEDICINE & PHARMACOTHERAPY 132(2020):9.

入库方式： OAI收割

来源：烟台海岸带研究所

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