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  4. 海岸带生物学与生物资源利用重点实验室
Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice

文献类型：期刊论文

作者Li, Lili3,4; Wang, Yuting1,3,4; Yuan, Jingyi2,3,4; Liu, Zhengyi3,4; Ye, Changqing1; Qin, Song3,4
刊名APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
出版日期2020-10-19
页码15
ISSN号0175-7598
关键词Undaria pinnatifida Hyperlipidemia Adiposity Gut microbiota Metabolome High-fat diet
DOI10.1007/s00253-020-10954-9
通讯作者Ye, Changqing(cqye@ntu.edu.cn) ; Qin, Song(sqin@yic.ac.cn)
英文摘要Dietary fiber has beneficial effects on obesity-related diseases and gut microbiota, contributing a key role in the interaction between dietary metabolism and host metabolism. Our objective was to investigate the cause of the improvement in multiple types of physiological states with seaweedUndaria pinnatifidatreatment on high-fat diet-fed mice and to evaluate whether its consequent anti-adiposity and anti-hyperlipidemic effects are associated with gut microbiota and its metabolomics regulation.U. pinnatifidaadministration in our experiment was shown to significantly decrease high-fat diet-induced body weight gain, as well as epididymal and abdominal adiposity.U. pinnatifidaintake also significantly reduced liver weight and serum triacylglycerol accumulation. We also found that improving effects ofU. pinnatifidaon high-fat diet-induced metabolic dysfunctions were associated with significant increase in specific bacteria, such asBacteroides acidifaciensandBacteroides ovatus, as well as metabolites, including short-chain fatty acids and tricarboxylic acid cycle intermediates. Our result provides a cheap dietary strategy to host metabolism improvement and obesity management.
WOS关键词INSULIN-RESISTANCE ; FIBER ; ACIDS ; SUPPLEMENTATION ; METABOLITES ; SEAWEED ; EXTRACT ; IMPACT ; CANCER ; MASS
资助项目Youth Innovation Promotion Association of Chinese Academy of Sciences[2018246] ; Science and Technology Program of Yantai[2020MSGY076]
WOS研究方向Biotechnology & Applied Microbiology
语种英语
WOS记录号WOS:000580713400002
资助机构Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Program of Yantai
源URL[http://ir.yic.ac.cn/handle/133337/28446]  
专题海岸带生物学与生物资源利用重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者Ye, Changqing; Qin, Song
作者单位1.Nantong Univ, Sch Publ Hlth, Nantong 226019, Peoples R China
2.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Li, Lili,Wang, Yuting,Yuan, Jingyi,et al. Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2020:15.
APA Li, Lili,Wang, Yuting,Yuan, Jingyi,Liu, Zhengyi,Ye, Changqing,&Qin, Song.(2020).Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,15.
MLA Li, Lili,et al."Undaria pinnatifidaimproves obesity-related outcomes in association with gut microbiota and metabolomics modulation in high-fat diet-fed mice".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020):15.

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来源：烟台海岸带研究所

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