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Paclitaxel-nanoparticles-loaded double network hydrogel for local treatment of breast cancer after surgical resection

文献类型：期刊论文

作者Wang, Mingchao3,4; Chen, Jian1; Li, Wenjun2,4; Zang, Fan3,4; Liu, Xuexia1; Qin, Song2,4
刊名MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
出版日期2020-09-01
卷号114页码:10
关键词Double network hydrogel Paclitaxel Nanoparticle Breast cancer Local treatment
ISSN号0928-4931
DOI10.1016/j.msec.2020.111046
通讯作者Li, Wenjun(wjli@yic.ac.cn) ; Qin, Song(sqin@yic.ac.cn)
英文摘要Anticancer drug-loaded hydrogels are a promising strategy for the local treatment of tumors such as breast cancer. We hypothesize that paclitaxel-nanoparticles-loaded double network (PTX-NPs-DN) hydrogel can deliver PTX locally and sustainably in the tumor resection cavity. In this study, hydrogels loaded with PTX-NPs were prepared via self-assembly of collagen and self-crosslinking of polyvinyl alcohol (PVA). The hydrogel with a porous structure has a compressive modulus of 33 kPa at a strain of 40%. In this system, PTX release presented a linear release kinetic over 10 days in vitro and higher accumulating concentrations of PTX in local adipose tissue than in plasma. The biocompatibility studies show that PTX-NPs-DN hydrogel did not induce cytotoxicity in different cell lines (MCF-7, L929s) and hemolysis in vitro nor inflammatory response in vivo. In vivo anti-tumor efficacy study, compared with all other groups, significantly decreased tumor weight and improved capacity to slow down tumor recurrences were observed in the group treated with PTX-NPs-DN hydrogel. In conclusion, this proof-of-concept study demonstrated the feasibility, tolerability and efficiency of PTX-NPs-DN hydrogel for the local treatment of breast cancer.
WOS关键词DRUG-DELIVERY SYSTEMS ; RELEASE ; PLGA ; BIOMATERIALS ; THERAPY
资助项目Major Science and Technology Innovation Project of Shandong Province (China)[2019JZZY011103] ; Marine Economy Innovation Development Demonstration Project[YHCX-SW-P-201701] ; Marine Economy Innovation Development Demonstration Project[YHCX-SW-Y-201701] ; National Key Research and Development Program of China[2016YFF0202304]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000579654700026
资助机构Major Science and Technology Innovation Project of Shandong Province (China) ; Marine Economy Innovation Development Demonstration Project ; National Key Research and Development Program of China
源URL[http://ir.yic.ac.cn/handle/133337/28455]  
专题海岸带生物学与生物资源利用重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者Li, Wenjun; Qin, Song
作者单位1.Qingdao Univ, Dept Oncol, Affiliated Yantai Yuhuangding Hosp, Yantai, Shandong, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
3.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Mingchao,Chen, Jian,Li, Wenjun,et al. Paclitaxel-nanoparticles-loaded double network hydrogel for local treatment of breast cancer after surgical resection[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2020,114:10.
APA Wang, Mingchao,Chen, Jian,Li, Wenjun,Zang, Fan,Liu, Xuexia,&Qin, Song.(2020).Paclitaxel-nanoparticles-loaded double network hydrogel for local treatment of breast cancer after surgical resection.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,114,10.
MLA Wang, Mingchao,et al."Paclitaxel-nanoparticles-loaded double network hydrogel for local treatment of breast cancer after surgical resection".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 114(2020):10.

入库方式： OAI收割

来源：烟台海岸带研究所

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