中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 烟台海岸带研究所
  3. 中国科学院烟台海岸带研究所
  4. 海岸带生物学与生物资源利用重点实验室
  5. 海岸带生物学与生物资源利用所重点实验室
Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment

文献类型：期刊论文

作者Li, Qing1,3; Mi, Yingqi1,2; Tan, Wenqiang1,3; Guo, Zhanyong1,3
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2020-12-01
卷号164页码:4279-4288
ISSN号0141-8130
关键词Chitosan Free radical-scavenging Chemical modification
DOI10.1016/j.ijbiomac.2020.08.250
通讯作者Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要Chitosan is an abundant and renewable polysaccharide, and chemical modification can be used to enhance the biological properties of chitosan. In this study, monophenol and ortho-diphenol were introduced to chitosan through chemical modification to get chitosan derivatives owned high antioxidant activity. Their free radical-scavenging activity against three free radicals and reduction ability was tested. Based on the four antioxidant assay, the antioxidant ability of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. The IC50 of inhibition of DPPH, hydroxyl ((OH)-O-center dot), and superoxide (O2 center dot-) radical-scavenging was 41-172, 10-89, and 14-38 mu g/mL, respectively. Meanwhile, ortho-diphenol was more efficient group than monophenol on the improvement of antioxidant ability of chitosan derivatives. The possible free radical-scavenging mechanism, including the number of the hydroxyl groups and the presence ortho-dihydroxy substitution for the antioxidant ability were discussed. In vitro studies demonstrated that the constructed chitosan derivatives have good biocompatibility, and good antioxidant capacity to reduce oxidative stress. Functionalization of chitosan with phenolic group allows the possible applications on the therapy of oxidative-related diseases. (C) 2020 Elsevier B.V. All rights reserved.
WOS关键词ANTIOXIDANT ACTIVITY ; INULIN DERIVATIVES ; OXIDATIVE STRESS ; FLAVONOIDS ; POLYPHENOLS ; MECHANISMS ; AGENTS ; DPPH ; DFT
资助项目Key Technology Research and Development Program of Shandong[2019GHY112010] ; Natural Science Foundation of Shandong[ZR2019BD064] ; National Key Research & Development Program of China[2019YFD0900705]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000588093700407
资助机构Key Technology Research and Development Program of Shandong ; Natural Science Foundation of Shandong ; National Key Research & Development Program of China
源URL[http://ir.yic.ac.cn/handle/133337/27513]  
专题烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
海岸带生物资源高效利用研究与发展中心
通讯作者Guo, Zhanyong
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Li, Qing,Mi, Yingqi,Tan, Wenqiang,et al. Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,164:4279-4288.
APA Li, Qing,Mi, Yingqi,Tan, Wenqiang,&Guo, Zhanyong.(2020).Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,164,4279-4288.
MLA Li, Qing,et al."Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 164(2020):4279-4288.

入库方式： OAI收割

来源：烟台海岸带研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。