Abnormal auditory-evoked gamma band oscillations in first-episode schizophrenia during both eye open and eye close states
文献类型:期刊论文
作者 | Junjie Wang10; Yingying Tang10; Adrian Curtin8,9; Raymond C.K. Chan6,7; Adrian Curtin6,7; Raymond C.K. Chan10; Tianhong Zhang10; Zhenying Qian10; Qian Guo10; Yu Li10 |
刊名 | Progress in Neuropsychopharmacology & Biological Psychiatry |
出版日期 | 2018 |
页码 | 279-286 |
关键词 | Eye open Eye close Auditory steady state response First-episode schizophrenia |
DOI | 10.1016/j.pnpbp.2018.04.016 |
文献子类 | 实证研究 |
英文摘要 | Abnormal auditory steady state response (ASSR) is a typical finding among schizophrenia patients, which is thought to directly reflect deficient gamma band oscillations in the brain. However, whether these ASSR alterations are state dependent, e.g. during eye-open or eye-closed conditions, has not yet been carefully elucidated in schizophrenia. Our study aimed to explore whether the abnormality of ASSR in patients with firstepisode schizophrenia (FEP) is altered under eye-open (EO) and eye-closed (EC) states. ASSR was elicited using 40 Hz click trains under EO and EC states. Twenty-eight healthy control subjects (HC) and thirty-three FEP individuals, 17 of whom were medication-naïve, were recruited. The event-related spectrum perturbation (ERSP) and intertrial coherence (ITC) in response to 40 Hz click sounds were quantified. Compared to HC group, FEP group showed a lower ITC and ERSP during EO state, as well as a decreased ITC during EC state. Our results suggest that abnormalities in gamma band oscillations among first-episode schizophrenia patients are present under both eye open and eye close states. Although differences in gamma band oscillations between EO and EC states within the FEP group were not observed, exploratory results suggest that state-sensitivity may be contingent on medication use. |
语种 | 英语 |
源URL | [http://ir.psych.ac.cn/handle/311026/34111] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China 2.Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University, Shanghai 200030, China 3.Brain Science and Technology Research Center, Shanghai Jiaotong University, Shanghai 200030, China 4.CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, China 5.University of Chinese Academy of Sciences, Shanghai 200031, China 6.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China 7.Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China 8.Med-X Institute, Shanghai Jiaotong University University, Shanghai 200300, China 9.School of Biomedical Engineering & Health Sciences, Drexel University, Philadelphia, PA 19104, USA 10.Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China |
推荐引用方式 GB/T 7714 | Junjie Wang,Yingying Tang,Adrian Curtin,et al. Abnormal auditory-evoked gamma band oscillations in first-episode schizophrenia during both eye open and eye close states[J]. Progress in Neuropsychopharmacology & Biological Psychiatry,2018:279-286. |
APA | Junjie Wang.,Yingying Tang.,Adrian Curtin.,Raymond C.K. Chan.,Adrian Curtin.,...&Jijun Wang.(2018).Abnormal auditory-evoked gamma band oscillations in first-episode schizophrenia during both eye open and eye close states.Progress in Neuropsychopharmacology & Biological Psychiatry,279-286. |
MLA | Junjie Wang,et al."Abnormal auditory-evoked gamma band oscillations in first-episode schizophrenia during both eye open and eye close states".Progress in Neuropsychopharmacology & Biological Psychiatry (2018):279-286. |
入库方式: OAI收割
来源:心理研究所
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