Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness
文献类型：期刊论文
| 作者 | Chen Ping1; Xie Qiuyou3; Wu Xiaoyan1; Huang Huiyuan1; Lv Wei3; Chen Lixiang1; Guo Yequn3; Zhang Shufei1; Hu Huiqing1; Wang You3 |
| 刊名 | Neuroscience Bulletin
 |
| 出版日期 | 2018 |
| 卷号 | 34期号:4页码:647-658 |
| ISSN号 | 1673-7067 |
| 关键词 | DEFAULT MODE NETWORK MEDIAL PREFRONTAL CORTEX PROPOFOL-INDUCED LOSS SEVERELY INJURED BRAIN BASAL GANGLIA FUNCTIONAL CONNECTIVITY INDIRECT PATHWAYS IMPAIRED CONSCIOUSNESS PARKINSONS-DISEASE VEGETATIVE STATE Mesocircuit Basal ganglia Posterior cingulate cortex Spectral dynamic causal modeling Connectome-based predictive modeling |
| 其他题名 | Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness |
| 英文摘要 | A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections (ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients’ outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level. |
| 资助项目 | [National Natural Science Foundation of China] ; [Natural Science Foundation of Guangdong Province, China] ; [Planned Science and Technology Project of Guangzhou Municipality, China] ; [Innovation Project of The Graduate School of South China Normal University] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6299978 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/37310]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.中国科学院心理研究所 2.广州大学 3.中国科学院广州地球化学研究所 |
| 推荐引用方式 GB/T 7714 | Chen Ping,Xie Qiuyou,Wu Xiaoyan,et al. Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness[J]. Neuroscience Bulletin,2018,34(4):647-658. |
| APA | Chen Ping.,Xie Qiuyou.,Wu Xiaoyan.,Huang Huiyuan.,Lv Wei.,...&Huang Ruiwang.(2018).Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness.Neuroscience Bulletin,34(4),647-658. |
| MLA | Chen Ping,et al."Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness".Neuroscience Bulletin 34.4(2018):647-658. |
入库方式： OAI收割
来源：心理研究所
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