Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia
文献类型:期刊论文
作者 | Xiu, Mei Hong1; Li, Zezhi5; Chen, Da Chun1; Chen, Song1; Curbo, Maile E.4; Wu, Hanjing Emily4; Tong, Yong Sheng1; Tan, Shu Ping1; Zhang, Xiang Yang2,3 |
刊名 | SCHIZOPHRENIA BULLETIN |
出版日期 | 2020-11-01 |
卷号 | 46期号:6页码:1498-1510 |
ISSN号 | 0586-7614 |
关键词 | schizophrenia BDNF superoxide dismutase interactive effect clinical symptoms cognitive function |
DOI | 10.1093/schbul/sbaa062 |
产权排序 | 4 |
文献子类 | 实证研究 |
英文摘要 | The pathogenesis and etiology of schizophrenia (SCZ) remains unclear. Accumulating studies showed that complex interrelationships between brain-derived neurotrophic factor (BDNF) and an imbalanced redox system has a crucial role in the psychopathology of SCZ. However, the influence of the interrelationships of BDNF and superoxide dismutase (SOD) on cognitive impairment and clinical symptomatology in drug-naive first-episode (DNFE) SCZ patients has not been studied thoroughly. Serum BDNF levels, plasma total SOD, manganese-SOD (Mn-SOD), copper/zinc-containing SOD (CuZn-SOD) activities, and malondialdehyde (MDA) levels were measured in 327 DNFE patients with SCZ and 391 healthy controls. Cognitive functions were measured using the Repeatable Battery for the Assessment of Neuropsychological status (RBANS) and clinical symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS). Compared with the controls, the DNFE patients had increased activities of total SOD and CuZn-SOD, and reduced levels of BDNF and MDA. BDNF levels were positively correlated with CuZn-SOD activity in patients. In addition, we found that elevated Mn-SOD and CuZn-SOD activities were related to PANSS depression factor. Moreover, an interactive effect of BDNF levels and Mn-SOD activity was associated with attentional index score in the patients. Therefore, our findings suggested that interrelationships between BDNF and antioxidant mechanisms might underlie the pathological mechanisms of cognitive impairments and symptomatology in the DNFE patients with SCZ. |
WOS关键词 | NEUROTROPHIC FACTOR LEVELS ; NEGATIVE SYNDROME SCALE ; OXIDATIVE STRESS ; CEREBROSPINAL-FLUID ; ASSOCIATION ; DOPAMINE ; SYMPTOMS ; ACID ; SOD1 ; METAANALYSIS |
资助项目 | National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | OXFORD UNIV PRESS |
WOS记录号 | WOS:000607041400020 |
源URL | [http://ir.psych.ac.cn/handle/311026/38155] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiang Yang |
作者单位 | 1.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX USA 5.Shanghai Jiao Tong Univ, Ren Ji Hosp, Dept Neurol, Sch Med, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Xiu, Mei Hong,Li, Zezhi,Chen, Da Chun,et al. Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia[J]. SCHIZOPHRENIA BULLETIN,2020,46(6):1498-1510. |
APA | Xiu, Mei Hong.,Li, Zezhi.,Chen, Da Chun.,Chen, Song.,Curbo, Maile E..,...&Zhang, Xiang Yang.(2020).Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia.SCHIZOPHRENIA BULLETIN,46(6),1498-1510. |
MLA | Xiu, Mei Hong,et al."Interrelationships Between BDNF, Superoxide Dismutase, and Cognitive Impairment in Drug-Naive First-Episode Patients With Schizophrenia".SCHIZOPHRENIA BULLETIN 46.6(2020):1498-1510. |
入库方式: OAI收割
来源:心理研究所
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