Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders
文献类型:期刊论文
作者 | Shi, Li-juan5,8; Zhou, Han-yu7,8; Wang, Yi7,8; Shen, Yan-mei6; Fang, Yu-min6; He, Yu-qiong6; Ou, Jian-jun6; Li, Hua-bing6; Luo, Xue-rong6; Cheung, Eric F. C.3 |
刊名 | ASIAN JOURNAL OF PSYCHIATRY |
出版日期 | 2020-10-01 |
卷号 | 53页码:11 |
ISSN号 | 1876-2018 |
关键词 | Empathy Autism spectrum disorders Early-onset schizophrenia fMRI Functional connectivity |
DOI | 10.1016/j.ajp.2020.102167 |
产权排序 | 2 |
文献子类 | 实证研究 |
英文摘要 | Empathy refers to the ability to understand other people's feelings and reacting emotionally to others. Impaired empathy has been reported in both individuals with schizophrenia and autism spectrum disorders (ASD). Despite overlaps, few studies have directly examined the neural mechanisms of impaired empathy in these two clinical groups. We used resting-state fMRI to investigate the neural correlates of empathic functioning in adolescents with ASD (N = 11), early-onset schizophrenia (EOS) (N = 20), and typically developing (TD) controls (N = 26). Their parents completed the Griffith Empathy Measure (GEM) to assess the adolescents' empathic capacity. We found that EOS and ASD participants both exhibited impaired empathy as measured by the GEM, especially in cognitive empathy (post-hoc ps < 0.05). Regions-of-interest-based functional connectivity revealed decreased connectivity between the salience network (SN) (i.e., the anterior insula and the anterior cingulate cortex) and core regions of the mentalizing network (e.g., the temporal-parietal junction and the precuneus), and among the SN and the bilateral superior temporal gyri (STG) and the left cerebellum in EOS participants. Subsequent comparisons revealed reduced grey matter volume in the STG bilaterally in both clinical groups. Increased resting-state functional connectivity within the social brain network was correlated with higher parent-reported scores of empathic capacity in TD adolescents, but such a brain-phenotype relationship was absent in the two clinical groups. These findings indicate that structural alterations and disturbed resting-state functional connectivity in the core empathy network may be the neural correlates of social cognitive deficits in individuals with EOS and ASD. |
WOS关键词 | SELF-REPORTED EMPATHY ; SOCIAL COGNITION ; ASPERGER-SYNDROME ; BRAIN RESPONSES ; EMOTIONAL EMPATHY ; METAANALYSIS ; DEFICITS ; IMPAIRMENTS ; CHILDREN ; ADULTS |
资助项目 | National Key Research and Development Programme[2016YFC0906402] ; National Natural Science Foundation China[31970997] ; China Postdoctoral Science Foundation[2016M601157] ; Humanity and Social Science Youth foundation of the Ministry of Education[17YJC190022] ; Natural Science Foundation of Hunan Province[2019JJ50149] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Australian NHMRC Senior Principal Research Fellowship[1105825] |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000595918300008 |
源URL | [http://ir.psych.ac.cn/handle/311026/38307] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia 2.Melbourne Hlth, Carlton, Vic, Australia 3.Castle Peak Hosp, Hong Kong, Peoples R China 4.Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Carlton, Vic, Australia 5.Hunan Univ Sci & Technol, Sch Educ, Xiangtan, Hunan, Peoples R China 6.Cent South Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha, Hunan, Peoples R China 7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 8.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Shi, Li-juan,Zhou, Han-yu,Wang, Yi,et al. Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders[J]. ASIAN JOURNAL OF PSYCHIATRY,2020,53:11. |
APA | Shi, Li-juan.,Zhou, Han-yu.,Wang, Yi.,Shen, Yan-mei.,Fang, Yu-min.,...&Chan, Raymond C. K..(2020).Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders.ASIAN JOURNAL OF PSYCHIATRY,53,11. |
MLA | Shi, Li-juan,et al."Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders".ASIAN JOURNAL OF PSYCHIATRY 53(2020):11. |
入库方式: OAI收割
来源:心理研究所
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