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Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study

文献类型：期刊论文

作者Shi, Hui4; Guan, Xiao Ni5; Liu, Dian Ying6; Zhu, Lin6; Wu, Zhi Wei1,2; Luo, Guo Zhi1,2; Wang, Jun5; Xiu, Mei Hong5; Zhang, Xiang Yang3
刊名PHARMACOPSYCHIATRY
出版日期2021-03-01
卷号54期号:02页码:68-74
关键词schizophrenia sex difference weight gain therapeutic response body mass index
ISSN号0176-3679
DOI10.1055/a-1353-6544
通讯作者Xiu, Mei Hong(xiumeihong97@163.com) ; Zhang, Xiang Yang(zhangxy9@gmail.com)
英文摘要Background Patients with antipsychotic-naive first-episode (ANFE) schizophrenia (SZ) can help clarify many confounding factors in determining sex differences in antipsychotic drug induced weight gain and its association with symptom improvement. Methods This 8-week longitudinal trial of ANFE patients with SZ enrolled 526 patients and 313 healthy controls. We evaluated bodyweight and the efficacy of antipsychotics on the Positive and Negative Syndrome Scale (PANSS) at baseline and at the end of week 8. Results Males and females after treatment showed no sex difference in weight gain, BMI increase, and percentage of weight gain. However, at baseline, male patients had more positive symptoms than female patients, and decreases in positive symptoms, general psychopathology, and total PANSS scores were less in male than female patients. Adjusting for confounding factors using multiple linear regression confirmed that weight gain was significantly associated with these decreases in PANSS symptoms only in men not women. Conclusions The relationship between weight gain and symptom reduction after 8 weeks of antipsychotic treatment exists only in male patients with ANFE SZ and not in female patients.
资助项目National Natural Science Foundation of China[81000509]
WOS研究方向Pharmacology & Pharmacy ; Psychiatry
语种英语
WOS记录号WOS:000621184900001
出版者GEORG THIEME VERLAG KG
源URL[http://ir.psych.ac.cn/handle/311026/38581]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Xiu, Mei Hong; Zhang, Xiang Yang
作者单位1.Shenzhen Kangning Hosp, Dept Psychiat, Shenzhen, Guangdong, Peoples R China
2.Shenzhen Mental Hlth Ctr Shenzhen, Shenzhen, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Capital Med Univ, Beijing Chao Yang Hosp, Dept Clin Psychol, Beijing, Peoples R China
5.Peking Univ, Beijing Hui Long Guan Hosp, Hui Long Guan Clin Med Sch, Beijing, Peoples R China
6.Third Peoples Hosp Ganzhou, Dept Psychiat, Ganzhou, Jiangxi, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Hui,Guan, Xiao Ni,Liu, Dian Ying,et al. Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study[J]. PHARMACOPSYCHIATRY,2021,54(02):68-74.
APA Shi, Hui.,Guan, Xiao Ni.,Liu, Dian Ying.,Zhu, Lin.,Wu, Zhi Wei.,...&Zhang, Xiang Yang.(2021).Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study.PHARMACOPSYCHIATRY,54(02),68-74.
MLA Shi, Hui,et al."Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study".PHARMACOPSYCHIATRY 54.02(2021):68-74.

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来源：心理研究所

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