Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease
文献类型:期刊论文
作者 | Zhang, Guanyu2,4; Ma, Jinghong5; Chan, Piu6; Ye, Zheng1,3 |
刊名 | FRONTIERS IN PSYCHOLOGY |
出版日期 | 2021-02-19 |
卷号 | 12页码:8 |
ISSN号 | 1664-1078 |
关键词 | Parkinson’ s disease dopamine sequential working memory mouse tracking dopamine D2 receptor agonist |
DOI | 10.3389/fpsyg.2021.631672 |
产权排序 | 1 |
文献子类 | 实证研究 |
英文摘要 | The ability to sequence thoughts and actions is impaired in Parkinson's disease (PD). In PD, a distinct error pattern has been found in the offline performance of sequential working memory. This study examined how PD's performance of sequential working memory unfolds over time using mouse tracking techniques. Non-demented patients with mild PD (N = 40) and healthy controls (N = 40) completed a computerized digit ordering task with a computer mouse. We measured response dynamics in terms of the initiation time, ordering time, movement time, and area under the movement trajectory curve. This approach allowed us to distinguish between the cognitive processes related to sequence processing before the actual movement (initiation time and ordering time) and the execution processes of the actual movement (movement time and area under the curve). PD patients showed longer initiation times, longer movement times, and more constrained movement trajectories than healthy controls. The initiation time and ordering time negatively correlated with the daily exposure to levodopa and D2/3 receptor agonists, respectively. The movement time positively correlated with the severity of motor symptoms. We demonstrated an altered temporal profile of sequential working memory in PD. Stimulating D1 and D2/3 receptors might speed up the maintenance and manipulation of sequences, respectively. |
资助项目 | National Natural Science Foundation of China[31771216] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; National Key Research and Development Program of China[2018YFC1312001] |
WOS研究方向 | Psychology |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:000625299500001 |
源URL | [http://ir.psych.ac.cn/handle/311026/38626] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Ye, Zheng |
作者单位 | 1.Chinese Acad Sci, Inst Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, Key Lab Primate Neurobiol, Shanghai, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 3.Shanghai Ctr Brain Sci & Brain Inspired Intellige, Shanghai, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing, Peoples R China 6.Capital Med Univ, Dept Neurol & Neurobiol, Natl Clin Res Ctr Geriatr Disorders, Xuanwu Hosp, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Guanyu,Ma, Jinghong,Chan, Piu,et al. Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease[J]. FRONTIERS IN PSYCHOLOGY,2021,12:8. |
APA | Zhang, Guanyu,Ma, Jinghong,Chan, Piu,&Ye, Zheng.(2021).Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease.FRONTIERS IN PSYCHOLOGY,12,8. |
MLA | Zhang, Guanyu,et al."Tracking Response Dynamics of Sequential Working Memory in Patients With Mild Parkinson's Disease".FRONTIERS IN PSYCHOLOGY 12(2021):8. |
入库方式: OAI收割
来源:心理研究所
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