The Role of Corticolimbic Circuitry in Chronic Pain
文献类型：期刊论文
| 作者 | Wang Fei-Xue1,3; Bi Yan-Zhi1,2; Hu Li1,2
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| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2021-04-01 |
| 卷号 | 48期号:4页码:393-406 |
| 关键词 | pain chronification emotion motivation corticolimbic circuitry |
| ISSN号 | 1000-3282 |
| DOI | 10.16476/j.pibb.2020.0195 |
| 通讯作者 | Bi Yan-Zhi(biyz@psych.ac.cn) |
| 英文摘要 | Chronic pain is one of the most common clinical symptoms and has been considered as a global healthcare problem. Currently, the underlying mechanisms of the transition from acute to chronic pain, also known as pain chronification, still remain incompletely understood. Neuroimaging studies indicated that the corticolimbic circuitry (prefrontal cortex, amygdala, hippocampus, nucleus accumbens, ventral tegmental area) is preferentially involved in encoding fluctuations of ongoing pain for various chronic pain conditions, suggesting the critical role of this neural circuitry in pain chronification. In this review, we first summarized the emotion, motivation, and memory dysfunctions and their corresponding structural and functional changes of the corticolimbic circuitry in chronic pain patients. Then, we reviewed the longitudinal brain imaging studies on low back pain chronification and highlighted the neuroimaging variables (i. e., the structural and functional properties of the corticolimbic circuitry) that could predict the transition from acute to chronic pain. For example, the functional connectivity between the medial prefrontal cortex and nucleus accumbens/hippocampus, as well as the functional connectivity between the dorsal medial prefrontal cortex and amygdala/nucleus accumbens could predict the development of chronic pain 1 year later. Besides, based on the existing theoretical model of chronic pain, we emphasized the critical role of the reinforcement learning of negative emotions as well as the dysfunctions of reward and stress systemin pain chronification. Finally, we pointed out the limitations of previous studies in this field and suggested future research directions for a better understanding of the neural mechanisms of chronic pain and pain chronification. |
| WOS关键词 | CHRONIC BACK-PAIN ; MEDIAL PREFRONTAL CORTEX ; GRAY-MATTER LOSS ; FUNCTIONAL CONNECTIVITY ; BRAIN MECHANISMS ; FIBROMYALGIA PATIENTS ; COGNITIVE IMPAIRMENT ; ALTERED STRUCTURE ; EMOTIONAL BRAIN ; MEMORY TRACES |
| 资助项目 | National Natural Science Foundation of China[31800926] ; National Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31822025] ; China Postdoctoral Science Foundation[2018M640191] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y8CX351005] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2018ZG01] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000644196400005 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| 源URL | [http://ir.psych.ac.cn/handle/311026/39081]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Bi Yan-Zhi |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Liaoning Normal Univ, Res Ctr Brain Cognit Neurosci, Dalian 116029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Fei-Xue,Bi Yan-Zhi,Hu Li. The Role of Corticolimbic Circuitry in Chronic Pain[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2021,48(4):393-406. |
| APA | Wang Fei-Xue,Bi Yan-Zhi,&Hu Li.(2021).The Role of Corticolimbic Circuitry in Chronic Pain.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,48(4),393-406. |
| MLA | Wang Fei-Xue,et al."The Role of Corticolimbic Circuitry in Chronic Pain".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 48.4(2021):393-406. |
入库方式： OAI收割
来源：心理研究所
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