Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2
文献类型:期刊论文
作者 | Duan, Ying1,3; Meng, Yiming1,3; Du, Wenjie1,3; Li, Ming2; Zhang, Jianjun1,3; Liang, Jing1,3; Li, Yonghui1,3; Sui, Nan1,3; Shen, Fang1,3 |
刊名 | ADDICTION BIOLOGY |
出版日期 | 2021-05-13 |
页码 | 11 |
ISSN号 | 1355-6215 |
关键词 | cocaine dopamine receptors incubation of craving L‐ type calcium channels motivation tree shrews |
DOI | 10.1111/adb.13053 |
产权排序 | 1 |
英文摘要 | The progressively increased motivation for cocaine during abstinence is closely associated with the dysfunction of dopamine (DA) system. As DA receptors also dynamically regulate L-type calcium channels (LTCCs), in this study we examined how DA receptors (D1R or D2R) and LTCCs (Ca(v)1.2 or Ca(v)1.3) exert their influences on cocaine-seeking in a tree shrew (Tupaia belangeri chinensis) model. First, we demonstrated the 'incubation' effect by showing tree shrews exhibited a significantly higher seeking behaviour on withdrawal day (WD) 45 than on WD1. Then, we confirmed that longer abstinence period induced higher D1R expression in the nucleus accumbens (NAc). Next, we showed that LTCCs in the NAc participated in drug seeking. Moreover, Ca(v)1.2 expression in the NAc was increased on WD45, and disruption of the Ca(v)1.2 inhibited drug seeking. Finally, we found that D1R antagonist blocked the increase of Ca(v)1.2 on drug-seeking test. Collectively, these findings suggest that D1R-mediated upregulation of Ca(v)1.2 is involved in the incubation of cocaine craving. |
WOS关键词 | RAT NUCLEUS-ACCUMBENS ; LONG-TERM ADAPTATION ; MEDIUM SPINY NEURONS ; CALCIUM-CHANNELS ; CA2+ CHANNELS ; GLUA1 TRAFFICKING ; NMDA RECEPTORS ; AMPA RECEPTORS ; INCUBATION ; D2 |
WOS研究方向 | Biochemistry & Molecular Biology ; Substance Abuse ; Biochemistry & Molecular Biology ; Substance Abuse |
出版者 | WILEY |
WOS记录号 | WOS:000649981400001 |
源URL | [http://ir.psych.ac.cn/handle/311026/39230] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Sui, Nan; Shen, Fang |
作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Univ Nebraska Lincoln, Dept Psychol, Lincoln, NE USA 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Duan, Ying,Meng, Yiming,Du, Wenjie,et al. Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2[J]. ADDICTION BIOLOGY,2021:11. |
APA | Duan, Ying.,Meng, Yiming.,Du, Wenjie.,Li, Ming.,Zhang, Jianjun.,...&Shen, Fang.(2021).Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2.ADDICTION BIOLOGY,11. |
MLA | Duan, Ying,et al."Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2".ADDICTION BIOLOGY (2021):11. |
入库方式: OAI收割
来源:心理研究所
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