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Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study

文献类型：期刊论文

作者Ferruccio, Naika P.13; Tosato, Sarah12,13; Lappin, Julia M.11; Heslin, Margaret10; Donoghue, Kim9; Giordano, Annalisa13; Lomas, Ben8; Reininghaus, Ulrich7; Onyejiaka, Adanna13; Chan, Raymond C. K.2
刊名SCHIZOPHRENIA BULLETIN
出版日期2021
卷号47期号:1页码:118-127
关键词neurological signs first-episode psychosis clinical outcome remission
ISSN号0586-7614
DOI10.1093/schbul/sbaa089
通讯作者Dazzan, Paola(paola.dazzan@kcl.ac.uk)
英文摘要Minor neurological signs are subtle deficits in sensory integration, motor coordination, and sequencing of complex motor acts present in excess in the early stages of psychosis. Still, it remains unclear whether at least some of these signs represent trait or state markers for psychosis and whether they are markers of long-term disease outcome of clinical utility. We examined the relationship between neurological function at illness onset assessed with the Neurological Evaluation Scale and subsequent illness course in 233 patients from AESOP-10 (Aetiology and Ethnicity in Schizophrenia and Other Psychoses), a 10-year follow-up study of a population-based cohort of individuals recruited at the time of their first episode of psychosis in the United Kingdom. In 56 of these patients, we also explored changes in neurological function over time. We included a group of 172 individuals without psychosis as controls. After 10 years, 147 (63%) patients had developed a non-remitting course of illness, and 86 (37%) a remitting course. Already at first presentation, patients who developed a non-remitting course had significantly more primary, motor coordination, and total signs than both remitting patients and healthy controls. While Motor Coordination signs did not change over time, rates of Primary, Sensory Integration, and Total signs increased, independently of illness course type. These findings suggest that motor coordination problems could be a useful early, quick, and easily detectable marker of subsequent clinical outcome. With other motor abnormalities, a measure of motor incoordination could contribute to the identification of the most vulnerable individuals, who could benefit from targeted and more assertive treatment approaches.
WOS关键词SOFT SIGNS ; 1ST-EPISODE SCHIZOPHRENIA ; FOLLOW-UP ; NEGATIVE SYMPTOMS ; CLINICAL-COURSE ; RATING-SCALE ; ABNORMALITIES ; STABILITY ; RISK ; PSYCHOPATHOLOGY
资助项目UK Medical Research Council[G0500817] ; Department of Health via the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000649368900016
出版者OXFORD UNIV PRESS
源URL[http://ir.psych.ac.cn/handle/311026/39396]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Dazzan, Paola
作者单位1.Univ Cambridge, Cambridge, England
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Trinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland
4.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England
5.South London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res NIHR Mental Hlth Biomed Res Ct, London, England
6.Kings Coll London, London, England
7.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Publ Mental Hlth, Heidelberg, Germany
8.Univ Nottingham, Dept Psychiat, Nottingham, England
9.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Addict, London, England
10.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Hlth Serv & Populat Res, London, England
推荐引用方式
GB/T 7714		 Ferruccio, Naika P.,Tosato, Sarah,Lappin, Julia M.,et al. Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study[J]. SCHIZOPHRENIA BULLETIN,2021,47(1):118-127.
APA Ferruccio, Naika P..,Tosato, Sarah.,Lappin, Julia M..,Heslin, Margaret.,Donoghue, Kim.,...&Dazzan, Paola.(2021).Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study.SCHIZOPHRENIA BULLETIN,47(1),118-127.
MLA Ferruccio, Naika P.,et al."Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study".SCHIZOPHRENIA BULLETIN 47.1(2021):118-127.

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