中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project

文献类型:期刊论文

作者Ding, Yu-Dan32,37; Yang, Ru36; Yan, Chao-Gan1,2,33,34,35; Chen, Xiao33,34; Bai, Tong-Jian3; Bo, Qi-Jing4; Chen, Guan-Mao5; Chen, Ning-Xuan33,34; Chen, Tao-Lin10,11; Chen, Wei6
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2021-04-01
卷号284页码:217-228
ISSN号0165-0327
关键词Major depressive disorder hemispheric asymmetry parameter of asymmetry fMRI Abbreviations ACC, Anterior cingulate gyrus DLPFC, Dorsolateral prefrontal cortex DMN, Default mode network DPARSF, Data Processing Assistant for Resting-State fMRI DSM, Diagnosic and Statistical Manual of Mental Disorders EEG, Electroencephalographic FC, Functional connectivity FDR, False discovery rate FEDN, First-episode, drug-naive FEF, Frontal eye fields fMRI, Functional magnetic resonance imaging HAMD, Hamilton Depression Rating Scale HC, Healthy control IFG, Inferior frontal gyrus IPL, Inferior parietal lobule IPS/SPL, Intraparietal sulcus/superior parietal lobule LMM, Linear mixed model MDD, Major depressive disorder MFG, Middle frontal gyrus MTG, Middle temporal gyrus PAS, Parameter of asymmetry PCC, Posterior cingulate cortex PET, Positron emission tomography ROIs, Regions of interest rs-fMRI, Resting-state fMRI rTMS, repetitive transcranial magnetic stimulation STS, Superior temporal sulcus VMHC, Voxel-mirrored homotopic connectivity
DOI10.1016/j.jad.2021.02.030
产权排序4
文献子类实证研究
英文摘要

Background: : Functional specialization is a feature of human brain for understanding the pathophysiology of major depressive disorder (MDD). The degree of human specialization refers to within and cross hemispheric interactions. However, most previous studies only focused on interhemispheric connectivity in MDD, and the results varied across studies. Hence, brain functional connectivity asymmetry in MDD should be further studied. Methods: : Resting-state fMRI data of 753 patients with MDD and 451 healthy controls were provided by RESTmeta-MDD Project. Twenty-five project contributors preprocessed their data locally with the Data Processing Assistant State fMRI software and shared final indices. The parameter of asymmetry (PAS), a novel voxel-based whole-brain quantitative measure that reflects interand intrahemispheric asymmetry, was reported. We also examined the effects of age, sex and clinical variables (including symptom severity, illness duration and three depressive phenotypes). Results: : Compared with healthy controls, patients with MDD showed increased PAS scores (decreased hemispheric specialization) in most of the areas of default mode network, control network, attention network and some regions in the cerebellum and visual cortex. Demographic characteristics and clinical variables have significant effects on these abnormalities. Limitations: : Although a large sample size could improve statistical power, future independent efforts are needed to confirm our results. Conclusions: : Our results highlight the idea that many brain networks contribute to broad clinical pathophysiology of MDD, and indicate that a lateralized, efficient and economical brain information processing system is disrupted in MDD. These findings may help comprehensively clarify the pathophysiology of MDD in a new hemispheric specialization perspective.

资助项目National Key R&D Program of China[2016YFC1307100] ; National Key R&D Program of China[2016YFC1306900] ; National Natural Science Foundation of China[81771447] ; National Natural Science Foundation of China[81630033] ; Natural Science Foundation of Hunan[2020JJ4784]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:000623621400026
源URL[http://ir.psych.ac.cn/handle/311026/38687]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Guo, Wen-Bin
作者单位1.Chinese Acad Sci, Res Ctr Lifespan Dev Mind & Brain Climb, Inst Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Int Big Data Ctr Depress Res, Inst Psychol, Beijing, Peoples R China
3.Anhui Med Univ, Hefei, Anhui, Peoples R China
4.Capital Med Univ, Beijing Anding Hosp, Beijing 100054, Peoples R China
5.Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
6.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China
7.Kunming Med Univ, Affiliated Hosp 1, Kunming 650221, Yunnan, Peoples R China
8.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China
9.Shanghai Jiao Tong Univ, Dept Psychiat, Sch Med, Shanghai 200240, Peoples R China
10.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
推荐引用方式
GB/T 7714
Ding, Yu-Dan,Yang, Ru,Yan, Chao-Gan,et al. Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,284:217-228.
APA Ding, Yu-Dan.,Yang, Ru.,Yan, Chao-Gan.,Chen, Xiao.,Bai, Tong-Jian.,...&Guo, Wen-Bin.(2021).Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project.JOURNAL OF AFFECTIVE DISORDERS,284,217-228.
MLA Ding, Yu-Dan,et al."Disrupted hemispheric connectivity specialization in patients with major depressive disorder: Evidence from the REST-meta-MDD Project".JOURNAL OF AFFECTIVE DISORDERS 284(2021):217-228.

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来源:心理研究所

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