Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment
文献类型：期刊论文
| 作者 | Jia,Xiuqin3,4; Li,Ying2; Li,Kuncheng1,2; Liang,Peipeng6; Fu,Xiaolan4,5
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| 刊名 | FRONTIERS IN AGING NEUROSCIENCE
 |
| 出版日期 | 2019-01-10 |
| 卷号 | 10页码:9 |
| 关键词 | Parkinson's Disease With Mild Cognitive Impairment Parietal Memory Network Arterial Spin Labeling (Asl) Functional Connectivity (Fc) Precuneus |
| ISSN号 | 1663-4365 |
| DOI | 10.3389/fnagi.2018.00427 |
| 产权排序 | 1 |
| 英文摘要 | Background: Mild cognitive impairment (MCI) frequently occurs in Parkinson's disease (PD). Neurovascular changes interact with neurodegenerative processes in PD. However, the deficits of cerebral blood flow (CBF) perfusion and the associated functional connectivity (FC) in PD patients with MCI (PD-MCI) remain unclear. Purpose: This study aimed to explore the specific neurovascular perfusion alterations in PD-MCI compared to PD with normal cognition (PD-NC) and healthy controls (HCs), and to further examine the resultant whole brain FC changes in the abnormal perfusion regions. Methods: Relative CBF (rCBF) was calculated using arterial spin labeling (ASL) in 54 patients with PD (27 patients with PD-NC and 27 patients with PD-MCI) and 25 HCs matched for age and gender ratio, who also underwent the structural MRI, resting-state functional MRI (rs-fMRI) and neuropsychological examinations. The gray matter (GM) changes in PD patients were analyzed using voxel-based morphometry (VBM). The alterations in rCBF perfusion and FC among groups were then analyzed respectively. Additionally, correlations between these alterations and neuropsychological performances were further examined. Results: Compared to HC, left caudate atrophy was detected in patients with PD. In comparison to both PD-NC and HC, patients with PD-MCI specifically exhibited hypoperfusion in the parietal memory network (PMN) in the precuneus (PCu) and decreased PCu-FC in the right striatum. Moreover, PCu perfusion and PCu-FC strengths in the right striatum were positively associated with memory performance in PD-MCI. Conclusions: These findings suggest that the posterior PMN dysfunction underlies memory deficits in PD-MCI. |
| URL标识 | 查看原文 |
| WOS关键词 | Parietal Memory Network ; Resting-state ; Functional Connectivity ; Gray-matter ; Cortical Hypoperfusion ; Perfusion ; Mri ; Patterns ; Quantification ; Single |
| WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000455391000001 |
| 国家 | China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/38665]  |
| 专题 | 心理研究所_脑与认知科学国家重点实验室 |
| 作者单位 | 1.Beijing Key Lab MRI & Brain Informat, Beijing, Peoples R China; 2.Capital Med Univ, Anzhen Hosp, Dept Radiol, Beijing, Peoples R China; 3.Capital Med Univ, Beijing Chaoyang Hosp, Dept Radiol, Beijing, Peoples R China; 4.Chinese Acad Sci, Inst Psychol, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China; 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Capital Normal Univ, Sch Psychol, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Jia,Xiuqin,Li,Ying,Li,Kuncheng,et al. Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment[J]. FRONTIERS IN AGING NEUROSCIENCE,2019,10:9. |
| APA | Jia,Xiuqin,Li,Ying,Li,Kuncheng,Liang,Peipeng,&Fu,Xiaolan.(2019).Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment.FRONTIERS IN AGING NEUROSCIENCE,10,9. |
| MLA | Jia,Xiuqin,et al."Precuneus Dysfunction in Parkinson's Disease With Mild Cognitive Impairment".FRONTIERS IN AGING NEUROSCIENCE 10(2019):9. |
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来源：心理研究所
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