Broadband terahertz recognizing conformational characteristics of a significant neurotransmitter gamma-aminobutyric acid
文献类型：期刊论文
| 作者 | Cheng, C; Zhu, ZJ; Li, SP; Ren, GH; Zhang, JB; Cong, HX; Peng, Y; Han, JG; Chang, C; Zhao, HW |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2019 |
| 卷号 | 9期号:35页码:20240-20247 |
| ISSN号 | 2046-2069 |
| 关键词 | TIME-DOMAIN SPECTROSCOPY MOLECULAR-STRUCTURE GABA-RECEPTORS CRYSTAL VIBRATIONS RHODOPSIN MOTION |
| DOI | 10.1039/c9ra02971k |
| 文献子类 | 期刊论文 |
| 英文摘要 | gamma-Aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the central nervous system, its conformational behavior is critical for selective biological functions and the process of signal transmission. Although this neuroactive molecule has been extensively studied, its vibrational properties related to the conformation and intermolecular interactions in the terahertz (THz) band have not been identified experimentally yet. In this study, we applied a broadband THz time-domain spectroscopy (THz-TDS) system from 0.5 to 18 THz to characterize a unique THz fingerprint of GABA. The density functional theory calculation results agree well with the THz experimental spectrum. The study shows that the vibrational modes of GABA at 1.15 and 1.39 THz originate from distinct collective vibrations. The absorptions at the higher THz frequencies also carry part of collective vibrations, but more reflect the specific and local vibrational information, including the skeleton deformation and the rocking of the functional groups, which are closely associated with the conformation and flexibility of GABA. This study may help to understand the conformational transitions of neurotransmitter molecules and the resonant response to THz waves. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/31983]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai 201210, Peoples R China; 2.East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China; 4.Tianjin Univ, Minist Educ, Ctr Terahertz Waves, Tianjin 300072, Peoples R China; 5.Tianjin Univ, Minist Educ, Coll Precis Instrument & Optoelect Engn, Key Lab Optoelect Informat & Technol, Tianjin 300072, Peoples R China; 6.Univ Shanghai Sci & Technol, Shanghai Key Lab Modern Opt Syst, 516 Jungong Rd, Shanghai 200093, Peoples R China; 7.Natl Innovat Inst Def Technol, Adv Interdisciplinary Technol Res Ctr, Beijing 100071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, C,Zhu, ZJ,Li, SP,et al. Broadband terahertz recognizing conformational characteristics of a significant neurotransmitter gamma-aminobutyric acid[J]. RSC ADVANCES,2019,9(35):20240-20247. |
| APA | Cheng, C.,Zhu, ZJ.,Li, SP.,Ren, GH.,Zhang, JB.,...&Zhao, HW.(2019).Broadband terahertz recognizing conformational characteristics of a significant neurotransmitter gamma-aminobutyric acid.RSC ADVANCES,9(35),20240-20247. |
| MLA | Cheng, C,et al."Broadband terahertz recognizing conformational characteristics of a significant neurotransmitter gamma-aminobutyric acid".RSC ADVANCES 9.35(2019):20240-20247. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。