Rapid Transmembrane Transport of DNA Nanostructures by Chemically Anchoring Artificial Receptors on Cell Membranes
文献类型：期刊论文
| 作者 | Li, M; Liu, JB; Deng, MY; Ge, ZL; Afshan, N; Zuo, XL; Li, Q |
| 刊名 | CHEMPLUSCHEM
 |
| 出版日期 | 2019 |
| 卷号 | 84期号:4页码:323-327 |
| 关键词 | MESSENGER-RNA DETECTION GOLD NANOPARTICLES DRUG-DELIVERY TETRAHEDRON TRACKING ELECTROPORATION NANOFLARES ACID |
| ISSN号 | 2192-6506 |
| DOI | 10.1002/cplu.201900025 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Highly efficient transmembrane transport of exogenous reagents into cells is of vital importance for developing drug-delivery systems. Conventionally, transmembrane transport of exogenous reagents was accomplished with the assistance of transfection agents or other artificial means. However, the high toxicity and low transport efficiency of current delivery techniques still remain to be solved. In this work, by anchoring artificial receptors onto cell membranes with a mild chemical reaction, we demonstrated that the exogenous reagent framework nucleic acids, namely tetrahedral DNA nanostructures (TDN) can bind onto cell membranes effectively by the hybridization between single-stranded DNA (ssDNA) and pendant ssDNA of TDN. The transport rate was greatly enhanced, with the endocytosis time could be as fast as 0.5h. Furthermore, the transport quantity was prominently improved, with around 30% of TDN endocytosed within 4h. Owing to its rapid transmembrane transport speed and improved endocytosis quantity, this artificial-receptor-mediated transmembrane transport is a promising tool for achieving rapid and highly efficient transmembrane transport of exogenous reagents. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/32177]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Inst Mol Med, Renji Hosp, Sch Med, Shanghai 200127, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Sch Chem & Chem Engn, Shanghai 20024, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol & Bioimaging Ctr, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, M,Liu, JB,Deng, MY,et al. Rapid Transmembrane Transport of DNA Nanostructures by Chemically Anchoring Artificial Receptors on Cell Membranes[J]. CHEMPLUSCHEM,2019,84(4):323-327. |
| APA | Li, M.,Liu, JB.,Deng, MY.,Ge, ZL.,Afshan, N.,...&Li, Q.(2019).Rapid Transmembrane Transport of DNA Nanostructures by Chemically Anchoring Artificial Receptors on Cell Membranes.CHEMPLUSCHEM,84(4),323-327. |
| MLA | Li, M,et al."Rapid Transmembrane Transport of DNA Nanostructures by Chemically Anchoring Artificial Receptors on Cell Membranes".CHEMPLUSCHEM 84.4(2019):323-327. |
入库方式： OAI收割
来源：上海应用物理研究所
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