Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release
文献类型：期刊论文
| 作者 | Shi, B; Ren, N; Gu, LY; Xu, G; Wang, RC; Zhu, TL; Zhu, Y; Fan, CH; Zhao, CC; Tian, H |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2019 |
| 卷号 | 58期号:47页码:16826-16830 |
| ISSN号 | 1433-7851 |
| 关键词 | PHOTODYNAMIC THERAPY CANCER H2S NANOPARTICLES |
| DOI | 10.1002/anie.201909883 |
| 文献子类 | 期刊论文 |
| 英文摘要 | NIR light responsive nanoplatforms hold great promise for on-demand drug release in precision cancer medicine. However, currently available systems utilize "always-on" photothermal transducers that lack target specificity, and thus inaccurately differentiate tumors from normal tissues. Developed here is a theranostic nanoplatform featuring H2S-mediated in situ production of NIR photothermal agents for imaging-guided and photocontrolled drug release. The system targets H2S-rich cancers. This nanoplatform shows H2S-activatable NIR-II emission and NIR light controllable release of the drug Camptothecin-11. Upon administering the system to HCT116 tumor-bearing mice, the tumor is greatly suppressed with minimal side effects, arising from the synergy of the cancer-specific and NIR light activated therapy. This theranostic nanoplatform thus sheds light on precision medicine with guidance through NIR-II imaging. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/32251]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China; 2.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China; 3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys,Shanghai Synchrotron Radi, Shanghai Adv Res Inst,Div Phys Biol,Zhangjiang La, Shanghai 201800, Peoples R China; 4.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys,Bioimaging Ctr, Shanghai Adv Res Inst,Zhangjiang Lab,Shanghai Syn, Shanghai 201800, Peoples R China; 5.Shanghai Jiao Tong Univ, Renji Hosp, Sch Chem & Chem Engn, Sch Med, Shanghai 200240, Peoples R China; 6.Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med, Sch Med, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, B,Ren, N,Gu, LY,et al. Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(47):16826-16830. |
| APA | Shi, B.,Ren, N.,Gu, LY.,Xu, G.,Wang, RC.,...&Tian, H.(2019).Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(47),16826-16830. |
| MLA | Shi, B,et al."Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.47(2019):16826-16830. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。