Direct ultrasensitive electrical detection of prostate cancer biomarkers with CMOS-compatible n- and p-type silicon nanowire sensor arrays
文献类型：期刊论文
| 作者 | Gao, Anran; Lu, Na; Dai, Pengfei; Fan, Chunhai; Wang, Yuelin; Li, Tie |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:21页码:13036-13042 |
| 关键词 | LABEL-FREE REAL-TIME ANTIGEN DNA BIOCHEMISTRY FABRICATION BIOSENSOR MEDICINE BIOLOGY MARKER |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c4nr03210a |
| 文献子类 | 期刊论文 |
| 英文摘要 | Sensitive and quantitative analysis of proteins is central to disease diagnosis, drug screening, and proteomic studies. Here, a label-free, real-time, simultaneous and ultrasensitive prostate-specific antigen (PSA) sensor was developed using CMOS-compatible silicon nanowire field effect transistors (SiNW FET). Highly responsive n- and p-type SiNW arrays were fabricated and integrated on a single chip with a complementary metal oxide semiconductor (CMOS) compatible anisotropic self-stop etching technique which eliminated the need for a hybrid method. The incorporated n- and p-type nanowires revealed complementary electrical response upon PSA binding, providing a unique means of internal control for sensing signal verification. The highly selective, simultaneous and multiplexed detection of PSA marker at attomolar concentrations, a level useful for clinical diagnosis of prostate cancer, was demonstrated. The detection ability was corroborated to be effective by comparing the detection results at different pH values. Furthermore, the real-time measurement was also carried out in a clinically relevant sample of blood serum, indicating the practicable development of rapid, robust, high-performance, and low-cost diagnostic systems. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/32432]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Sci & Technol Microsyst Lab, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China 2.Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China 3.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Anran,Lu, Na,Dai, Pengfei,et al. Direct ultrasensitive electrical detection of prostate cancer biomarkers with CMOS-compatible n- and p-type silicon nanowire sensor arrays[J]. NANOSCALE,2014,6(21):13036-13042. |
| APA | Gao, Anran,Lu, Na,Dai, Pengfei,Fan, Chunhai,Wang, Yuelin,&Li, Tie.(2014).Direct ultrasensitive electrical detection of prostate cancer biomarkers with CMOS-compatible n- and p-type silicon nanowire sensor arrays.NANOSCALE,6(21),13036-13042. |
| MLA | Gao, Anran,et al."Direct ultrasensitive electrical detection of prostate cancer biomarkers with CMOS-compatible n- and p-type silicon nanowire sensor arrays".NANOSCALE 6.21(2014):13036-13042. |
入库方式： OAI收割
来源：上海应用物理研究所
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