Fabrication of guanidinylated chitosan nanoparticles loaded with bioactive factors for facilitating wound healing
文献类型：期刊论文
| 作者 | Li, Ling3; Xing, Ronge2 ; Li, Jinguo1; Li, Pengcheng2
|
| 刊名 | INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
 |
| 出版日期 | 2020-09-12 |
| 页码 | 7 |
| 关键词 | Bioactive factors chitosan guanidine nanoparticle scar wound healing |
| ISSN号 | 0091-4037 |
| DOI | 10.1080/00914037.2020.1817017 |
| 通讯作者 | Li, Jinguo(likang8688@163.com) ; Li, Pengcheng(pcli@qdio.ac.cn) |
| 英文摘要 | Developing wound dressings that improve healing and minimize scarring is of great importance. Chitosan, widely used in biomedical materials, and the chemicals, food and cosmetics fields, shows poor wound healing abilities. In addition, bioactive factors such as epidermal growth factor (EGF) and 1,25-dihydroxyvitamin D-3(VD3), which are significant for stimulating skin fibroblasts and keratinocyte proliferation, have limited applicability because they are unstable in wound dressing fabrication and storage. Here we prepared guanidinylated chitosan nanoparticles loaded with five different bioactive factors (CGNP), including EGF, ascorbic acid (VC), hydrocortisone, insulin and VD3, and evaluated their wound healing ability. The results show that the size of CGNPs was about 200 nm, which is suitable for cellular uptake. CGNPs were used to treat skin wounds induced on Wistar rats. With the treatment, complete healing was observed after 24 days, while untreated wounds and those treated with chitosan were irregular. Moreover, wounds treated with CGNP1 showed color and smoothness similar to normal skin after recovery after 28 days. CGNPs may be possible wound dressings for stable delivery of bioactive factors, enhancement of wound healing and avoidance scarring. |
| 资助项目 | NSFC-Shandong Union[U1406402-5] ; independent innovation Project of Shandong Province[2013CXB80203] ; CAS STS Program[KFJ-SW-STS-143] ; Public Science and Technology Research Funds Projects of Ocean[201405038-2] ; Public Science and Technology Research Funds Projects of Ocean[201305016-2] |
| WOS研究方向 | Materials Science ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000571078400001 |
| 出版者 | TAYLOR & FRANCIS AS |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/168917]  |
| 专题 | 中国科学院海洋研究所 |
| 通讯作者 | Li, Jinguo; Li, Pengcheng |
| 作者单位 | 1.Shandong Wei Kang Biomed Technol Co Ltd, Linyi, Shandong, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China 3.Hunan Univ Sci & Engn, Yongzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ling,Xing, Ronge,Li, Jinguo,et al. Fabrication of guanidinylated chitosan nanoparticles loaded with bioactive factors for facilitating wound healing[J]. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS,2020:7. |
| APA | Li, Ling,Xing, Ronge,Li, Jinguo,&Li, Pengcheng.(2020).Fabrication of guanidinylated chitosan nanoparticles loaded with bioactive factors for facilitating wound healing.INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS,7. |
| MLA | Li, Ling,et al."Fabrication of guanidinylated chitosan nanoparticles loaded with bioactive factors for facilitating wound healing".INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2020):7. |
入库方式： OAI收割
来源：海洋研究所
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