中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants

文献类型:期刊论文

作者Li, Xiaomin1,2,3,4; Xing, Ronge1,2,3,4; Xu, Chaojie1,2,3,4; Liu, Song2,3,4; Qin, Yukun2,3,4; Li, Kecheng2,3,4; Yu, Huahua2,3,4; Li, Pengcheng2,3,4
刊名CARBOHYDRATE POLYMERS
出版日期2021-07-15
卷号264页码:16
ISSN号0144-8617
关键词Chitosan Quaternized chitosan Immunostimulatory activities Immune mechanism Vaccine adjuvant
DOI10.1016/j.carbpol.2021.118050
通讯作者Xing, Ronge(xingronge@qdio.ac.cn)
英文摘要Vaccines have always been the most effective preventive treatment. Advancements in the field of vaccine is inseparable from adjuvants. Adjuvants are substances added to vaccines to enhance immunogenicity and induce a stronger immune response. Chitosan fascinated considerable attention as vaccine adjuvant due to its unique physicochemical and biological properties. Many studies have shown that chitosan and its derivatives can effectively activate antigen-presenting cells and induce cytokine stimulation to produce an effective immune response and promote the balance of Th1/Th2 response. Among many derivatives, the quaternized chitosan performs better. This review presents the main factors affecting the adjuvant performance of chitosan and quaternized chitosan firstly. Then, we introduced not only the immune response they may cause, but also their metabolic research in detail. Furthermore, their future prospects are forecasted. Overall, chitosan and quaternized chitosan are both promising adjuvant materials, and quaternized chitosan shows greater potential.
资助项目National Key R&D Program of China[2018YFC0311300] ; Key Research and Development Program of Shandong Province[2019GHY112015] ; Key Research and Development Program of Shandong Province[2019YYSP028]
WOS研究方向Chemistry ; Polymer Science
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000647409300001
源URL[http://ir.qdio.ac.cn/handle/337002/170943]  
专题中国科学院海洋研究所
通讯作者Xing, Ronge
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
4.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714
Li, Xiaomin,Xing, Ronge,Xu, Chaojie,et al. Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants[J]. CARBOHYDRATE POLYMERS,2021,264:16.
APA Li, Xiaomin.,Xing, Ronge.,Xu, Chaojie.,Liu, Song.,Qin, Yukun.,...&Li, Pengcheng.(2021).Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants.CARBOHYDRATE POLYMERS,264,16.
MLA Li, Xiaomin,et al."Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants".CARBOHYDRATE POLYMERS 264(2021):16.

入库方式: OAI收割

来源:海洋研究所

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