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Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3

文献类型：期刊论文

作者Shi, Xiao-Shan2,3,4; Meng, Ling-Hong3,4; Li, Xin3,4; Wang, Dun-Jia2; Zhou, Xing-Wang2; Du, Feng-Yu5; Wang, Bin-Gui1,3,4; Li, Xiao-Ming1,3,4
刊名CHEMISTRY & BIODIVERSITY
出版日期2020-11-03
页码9
关键词Trichoderma koningiopsis Artemisia argyi polyketides terpenoids antibacterial activity
ISSN号1612-1872
DOI10.1002/cbdv.202000566
通讯作者Li, Xiao-Ming(lixmqd@qdio.ac.cn)
英文摘要The AcOEt extract of Artemisia argyi-derived fungus Trichoderma koningiopsis QA-3 showed potent inhibitory activity against pathogenic bacteria. Fractionation of the extract resulted in the isolation of three new polyketides (1-3) and two new terpenoids (4 and 5), together with three known metabolites (6-8). Their chemical structures were analyzed by NMR spectra, ECD, HR-ESI-MS or HR-EI-MS, optical rotation, and X-ray crystallographic data, as well as by comparison with literature reports. In the antibacterial assays, 3-hydroxyharziandione (4) showed potent activity against human pathogen Escherichia coli with an MIC value of 0.5 mu g/mL, while 6-(3-hydroxypent-1-en-1-yl)-2H-pyran-2-one exhibited strong activity against marine-derived aquatic pathogen Micrococcus luteus with an MIC value of 1.0 mu g/mL.
资助项目National Natural Science Foundation of China[31870328] ; Taishan Scholar Program from Shandong Province, China[ts201511060]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000584000700001
出版者WILEY-V C H VERLAG GMBH
源URL[http://ir.qdio.ac.cn/handle/337002/168995]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Li, Xiao-Ming
作者单位1.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Hubei Normal Univ, Coll Chem & Chem Engn, Cihu Rd 11, Huangshi 435002, Hubei, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
5.Qingdao Agr Univ, Coll Chem & Pharm, Changcheng Rd 700, Qingdao 266109, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Xiao-Shan,Meng, Ling-Hong,Li, Xin,et al. Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3[J]. CHEMISTRY & BIODIVERSITY,2020:9.
APA Shi, Xiao-Shan.,Meng, Ling-Hong.,Li, Xin.,Wang, Dun-Jia.,Zhou, Xing-Wang.,...&Li, Xiao-Ming.(2020).Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3.CHEMISTRY & BIODIVERSITY,9.
MLA Shi, Xiao-Shan,et al."Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3".CHEMISTRY & BIODIVERSITY (2020):9.

入库方式： OAI收割

来源：海洋研究所

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