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Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus Penicillium cyclopium SD-413

文献类型：期刊论文

作者Li, Yan-He2,3,4; Li, Xiao-Ming1,2,3; Li, Xin1,2,3; Yang, Sui-Qun1,2,3; Shi, Xiao-Shan1,2,3; Li, Hong-Lei1,2,3; Wang, Bin-Gui2,3,4
刊名MARINE DRUGS
出版日期2020-11-01
卷号18期号:11页码:8
关键词Penicillium cyclopium marine sediment-derived fungus quinazoline alkaloid polyketide derivatives antibacterial activity
DOI10.3390/md18110553
通讯作者Li, Hong-Lei(lihonglei@qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
英文摘要Nine secondary metabolites (1-9), including two new polyketide derivatives 9-dehydroxysargassopenilline A (4) and 1,2-didehydropeaurantiogriseol E (5), along with seven known related secondary metabolites (1-3 and 6-9), were isolated and identified from the deep sea-derived fungus Penicillium cyclopium SD-413. Their structures were elucidated on the basis of 1D/2D NMR spectroscopic and mass spectrometric analysis and the absolute configurations were determined by the combination of NOESY correlations and time-dependent density functional (TDDFT) ECD calculations. Compounds 1-9 inhibited some pathogenic bacteria including Escherichia coli, E. ictaluri, Edwardsiella tarda, Micrococcus luteus, Vibrio anguillarum, and V. harveyi, with MIC (minimum inhibitory concentration) values ranging from 4 to 32 mu g/mL.
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401] ; National Natural Science Foundation of China[31700043] ; Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2016ASKJ14] ; Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences[KEXUE2018G28] ; Taishan Scholar Project from Shandong Province ; Qingdao National Laboratory for Marine Science and Technology[OF2019NO03]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000593309800001
出版者MDPI
源URL[http://ir.qdio.ac.cn/handle/337002/169288]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Li, Hong-Lei; Wang, Bin-Gui
作者单位1.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
4.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yan-He,Li, Xiao-Ming,Li, Xin,et al. Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus Penicillium cyclopium SD-413[J]. MARINE DRUGS,2020,18(11):8.
APA Li, Yan-He.,Li, Xiao-Ming.,Li, Xin.,Yang, Sui-Qun.,Shi, Xiao-Shan.,...&Wang, Bin-Gui.(2020).Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus Penicillium cyclopium SD-413.MARINE DRUGS,18(11),8.
MLA Li, Yan-He,et al."Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus Penicillium cyclopium SD-413".MARINE DRUGS 18.11(2020):8.

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来源：海洋研究所

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