Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms
文献类型：期刊论文
| 作者 | Wang, Ya-Nan1,2,4 ; Meng, Ling-Hong1,4; Wang, Bin-Gui1,3,4
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2020-12-01 |
| 卷号 | 18期号:12页码:26 |
| 关键词 | deep-sea fungi deep-sea actinomycetes secondary metabolites bioactivity |
| DOI | 10.3390/md18120614 |
| 通讯作者 | Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| 英文摘要 | Deep sea has an extreme environment which leads to biodiversity of microorganisms and their unique physical and biochemical mechanisms. Deep-sea derived microorganisms are more likely to produce novel bioactive substances with special mechanism of action for drug discovery. This article reviews secondary metabolites with biological activities such as anti-tumor, anti-bacterial, anti-viral, and anti-inflammatory isolated from deep-sea fungi and bacteria during 2018-2020. Effective methods for screening and obtaining natural active compounds from deep-sea microorganisms are also summarized, including optimizing the culture conditions, using genome mining technology, biosynthesis and so on. The comprehensive application of these methods makes broader prospects for the development and application of deep sea microbial bioactive substances. |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401] ; Natural Science Foundation of China[41976090] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250] ; Taishan Scholar Project from Shandong Province |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000602115300001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/169569]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Meng, Ling-Hong; Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ya-Nan,Meng, Ling-Hong,Wang, Bin-Gui. Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms[J]. MARINE DRUGS,2020,18(12):26. |
| APA | Wang, Ya-Nan,Meng, Ling-Hong,&Wang, Bin-Gui.(2020).Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms.MARINE DRUGS,18(12),26. |
| MLA | Wang, Ya-Nan,et al."Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms".MARINE DRUGS 18.12(2020):26. |
入库方式： OAI收割
来源：海洋研究所
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