Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin-Strongylocentyotus internedius
文献类型：期刊论文
| 作者 | Wang, Qing-Chi1,2,3,4 ; Wei, Maosheng1,2,3,4; Yue, Yang1,2,3,4; Wu, Ning1,2,3,4; Wang, Jing1,2,3,4; Zhang, Quanbin1,2,3,4
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2021-04-15 |
| 卷号 | 258页码:14 |
| 关键词 | Strongylocentyotus internedius Glycogen Structural characterization Immunostimulatory activity RAW264.7 macrophage |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2021.117701 |
| 通讯作者 | Zhang, Quanbin(qbzhang@qdio.ac.cn) |
| 英文摘要 | Sea urchin possesses both high nutritional and medicinal value. It contains diverse biological active polysaccharides. But there are few studies on its glycogen. In the current study, a glucan (MSGA) was separated from Strongylocentyotus internedius and purified by ion exchange and gel filtration column. Chemical analysis revealed that MSGA with 2.65 x 10(7) Da is made up entirely of glucose. The analysis of methylation, NMR and mass spectrum demonstrated that MSGA is a highly branched glycogen with alpha-(1 -> 4) linked gluconic backbone and branched at C-6 (one branch per five residues). In addition, MSGA showed good in vitro immunostimulatory activity via NF-kappa B and MAPKs pathways. It is considered that high degree of branching is necessary for its activity. However, the relationship between structure and immunostimulatory activity of natural glycogens is difficult to elucidate because the difference in their structural properties. Therefore, much more research is needed in this area. |
| 资助项目 | National Key R&D Program of China[2018YFD0901104] ; National Key R&D Program of China[2019YFD0900705] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000620151600005 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/170132]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Zhang, Quanbin |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Earth Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qing-Chi,Wei, Maosheng,Yue, Yang,et al. Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin-Strongylocentyotus internedius[J]. CARBOHYDRATE POLYMERS,2021,258:14. |
| APA | Wang, Qing-Chi,Wei, Maosheng,Yue, Yang,Wu, Ning,Wang, Jing,&Zhang, Quanbin.(2021).Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin-Strongylocentyotus internedius.CARBOHYDRATE POLYMERS,258,14. |
| MLA | Wang, Qing-Chi,et al."Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin-Strongylocentyotus internedius".CARBOHYDRATE POLYMERS 258(2021):14. |
入库方式： OAI收割
来源：海洋研究所
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