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Visible light driven photoelectrochemical thrombin aptasensor based on uniform TiO2 nanotube arrays modified with CuOx and perylene-3,4,9,10-tetracarboxylic acid

文献类型：期刊论文

作者Zhang, Qiaoxia3,4; Lyu, Haoyuan3,4; Li, Ning3,4; Liu, Qing3,4; Zhang, Xianxi5; Zhang, Xiao1; Wang, Xiutong2; Qingyun, Liu3,4
刊名ELECTROCHIMICA ACTA
出版日期2020-09-10
卷号354页码:9
关键词Thrombin Photoelectrochemical aptasensor TiO2/CuOx Perylene-3,4,9,10-tetracarboxylic acid
ISSN号0013-4686
DOI10.1016/j.electacta.2020.136774
通讯作者Wang, Xiutong() ; Qingyun, Liu(qyliu@sdust.edu.cn)
英文摘要In this work, a sensitive signal-off photoelectrochemical (PEC) thrombin aptasensor with satisfying specificity is proposed, in which the evident initial photocurrent response is produced by the photoanode and the signal amplification strategy toward the target is based on the specific bio-affinity properties between thrombin and their aptamers. The photoanode was fabricated with uniform TiO2 nanotube arrays decorated with CuOx and perylene-3,4,9,10-tetracarboxylic acid (PTCA). After the decoration of CuOx and PTCA, both possessing a strong absorption in visible region, the photocurrent response is improved greatly. Pt nanoparticles were modified on the photoanode electrode to immobilize thrombin aptamers, which could obviously improve the conductivity of the photoanode electrode owing to the excellent conductivity of Pt nanoparticles. The non-conductive complex leads to dramatical decrease in the photocurrent value due to the steric hinder effect. Based on the joint action of evident photocurrent response of photoanode and significant signal amplification strategy, the aptasensor in this project offers a wide linear range from 0.0003 nM to 10 nM, with a detection limit (3S/N) of thrombin down to 55 fM. Moreover, the as-fabricated aptasensor exhibits acceptable selectivity and stability, providing a meaningful attempt for the detection of thrombin. (C) 2020 Elsevier Ltd. All rights reserved.
资助项目National Natural Science Foundation of China[21971152] ; Natural Science Foundation of Shandong Province[ZR2018MB002]
WOS研究方向Electrochemistry
语种英语
WOS记录号WOS:000569145000012
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://ir.qdio.ac.cn/handle/337002/168798]  
专题海洋研究所_海洋腐蚀与防护研究发展中心
通讯作者Wang, Xiutong; Qingyun, Liu
作者单位1.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China
2.Chinese Acad Sci, Key Lab Marine Environm Corros & Biofouling, Inst Oceanol, Qingdao 266071, Peoples R China
3.Shandong Univ Sci & Technol, Coll Chem & Biol Engn, State Key Lab Min Disaster Prevent & Control Cofo, Qingdao 266590, Peoples R China
4.Shandong Univ Sci & Technol, Minist Sci & Technol, Qingdao 266590, Peoples R China
5.Liaocheng Univ, Shandong Prov Key Lab, Collaborat Innovat Ctr Chem Energy Storage & Nove, Sch Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Qiaoxia,Lyu, Haoyuan,Li, Ning,et al. Visible light driven photoelectrochemical thrombin aptasensor based on uniform TiO2 nanotube arrays modified with CuOx and perylene-3,4,9,10-tetracarboxylic acid[J]. ELECTROCHIMICA ACTA,2020,354:9.
APA Zhang, Qiaoxia.,Lyu, Haoyuan.,Li, Ning.,Liu, Qing.,Zhang, Xianxi.,...&Qingyun, Liu.(2020).Visible light driven photoelectrochemical thrombin aptasensor based on uniform TiO2 nanotube arrays modified with CuOx and perylene-3,4,9,10-tetracarboxylic acid.ELECTROCHIMICA ACTA,354,9.
MLA Zhang, Qiaoxia,et al."Visible light driven photoelectrochemical thrombin aptasensor based on uniform TiO2 nanotube arrays modified with CuOx and perylene-3,4,9,10-tetracarboxylic acid".ELECTROCHIMICA ACTA 354(2020):9.

入库方式： OAI收割

来源：海洋研究所

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