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The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review

文献类型：期刊论文

作者Zhang, Jiajia2,3,4; Wu, Ning2,4; Shi, Dayong1,2,3,4
刊名MINI-REVIEWS IN MEDICINAL CHEMISTRY
出版日期2021
卷号21期号:7页码:803-815
关键词Signaling pathway mammalian target of rapamycin protein tyrosine phosphatase 1b dipeptidase 4 cancer diabetes pharmacology target compounds
ISSN号1389-5575
DOI10.2174/1389557520666201113110406
通讯作者Wu, Ning(wuning@qdio.ac.cn) ; Shi, Dayong(shidayong@sdu.edu.cn)
英文摘要Background: The mammalian target of rapamycin (mTOR), protein tyrosine phosphatase 1b (PTP1B) and dipeptidase 4 (DPP4) signaling pathways regulate eukaryotic cell proliferation and metabolism. Previous researches described different transduction mechanisms in the progression of cancer and diabetes. Methodology: We reviewed recent advances in the signal transduction pathways of mTOR, PTP1B and DPP4 regulation and determined the crosstalk and common pathway in diabetes and cancer. Results: We showed that according to numerous past studies, the proteins participate in the signaling networks for both diseases. Conclusion: There are common pathways and specific proteins involved in diabetes and cancer. This article demonstrates and explains the potential mechanisms of association and future prospects for targeting these proteins in pharmacological studies.
资助项目National Natural Science Foundation of China[81803375] ; National Natural Science Foundation of China[81773586] ; National Natural Science Foundation of China[81903354] ; National Natural Science Foundation of China[81872906]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000631285400002
出版者BENTHAM SCIENCE PUBL LTD
源URL[http://ir.qdio.ac.cn/handle/337002/170278]  
专题中国科学院海洋大科学研究中心
通讯作者Wu, Ning; Shi, Dayong
作者单位1.Shandong Univ, State Key Lab Microbial Technol, Jinan, Shandong, Peoples R China
2.Lab Marine Drugs & Bioprod Qingdao Natl Lab Marin, Qingdao, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Jiajia,Wu, Ning,Shi, Dayong. The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2021,21(7):803-815.
APA Zhang, Jiajia,Wu, Ning,&Shi, Dayong.(2021).The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review.MINI-REVIEWS IN MEDICINAL CHEMISTRY,21(7),803-815.
MLA Zhang, Jiajia,et al."The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review".MINI-REVIEWS IN MEDICINAL CHEMISTRY 21.7(2021):803-815.

入库方式： OAI收割

来源：海洋研究所

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