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Tumor Vessel Targeted Self-Assemble Nanoparticles for Amplification and Prediction of the Embolization Effect in Hepatocellular Carcinoma

文献类型：期刊论文

作者Wang, Yaqin1; Shang, Wenting3; Zhong, Hongshan1; Luo, Ting1; Niu, Meng1; Xu, Ke1; Tian, Jie2,3
刊名ACS NANO
出版日期2020-11-24
卷号14期号:11页码:14907-14918
关键词coagulation cascade tumor embolism vessel density hepatocellular carcinoma self-assemble nanoparticle
ISSN号1936-0851
DOI10.1021/acsnano.0c04341
通讯作者Niu, Meng(guanjh@cmu.edu.cn) ; Xu, Ke(kxu@cmu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Vessel embolization is recommended as the first line treatment for unresectable hepatocellular carcinoma (HCC). However, owing to the imprecise vessel embolization and heterogeneous response performance among patients, its survival benefits are often compromised. Herein, we reported an innovative strategy to extensively embolize the tumor by triggering the coagulation cascade, and predict the embolization effect with vessel density assessment. We synthesized manganese dioxide (MnO2)/verteporfin (BPD) nanocomposites, in which BPD bound to the tumor vessel endothelial cells (TVECs) and MnO2 nanosheets served as the carrier. MnO2 was reduced to Mn2+ ions and self-assembled with BPD to produce nanoBPD, resulting in enhanced TVECs apoptosis and coagulation cascade compared to that with free BPD. Furthermore, multimodal imaging was used to visualize tumor vessel density, which can be used as a predictor to identify the patients who would benefit from embolization. Our findings describe a promising strategy for both tumor eradication and effect prediction to improve survival benefits in unresectable HCC patients.
资助项目National Key R&D Program of China[2017YFA0700401] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81630053] ; National Natural Science Foundation of China[81971680] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81601584] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81771944] ; Chinese Academy of Sciences[XDB01030200]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000595533800041
出版者AMER CHEMICAL SOC
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences
源URL[http://ir.ia.ac.cn/handle/173211/42584]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Niu, Meng; Xu, Ke; Tian, Jie
作者单位1.China Med Univ, Dept Intervent Radiol, Affiliated Hosp 1, Shenyang 110000, Liaoning, Peoples R China
2.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yaqin,Shang, Wenting,Zhong, Hongshan,et al. Tumor Vessel Targeted Self-Assemble Nanoparticles for Amplification and Prediction of the Embolization Effect in Hepatocellular Carcinoma[J]. ACS NANO,2020,14(11):14907-14918.
APA Wang, Yaqin.,Shang, Wenting.,Zhong, Hongshan.,Luo, Ting.,Niu, Meng.,...&Tian, Jie.(2020).Tumor Vessel Targeted Self-Assemble Nanoparticles for Amplification and Prediction of the Embolization Effect in Hepatocellular Carcinoma.ACS NANO,14(11),14907-14918.
MLA Wang, Yaqin,et al."Tumor Vessel Targeted Self-Assemble Nanoparticles for Amplification and Prediction of the Embolization Effect in Hepatocellular Carcinoma".ACS NANO 14.11(2020):14907-14918.

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来源：自动化研究所

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