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A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence

文献类型：期刊论文

作者Zhou, Tianjun3,4,7; Liang, Xiaolong2; Wang, Peifeng3,4,7; Hu, Yueyang3,4,7; Qi, Yafei3; Jin, Yushen5; Du, Yang3,6; Fang, Chihua4; Tian, Jie1,3
刊名ACS NANO
出版日期2020-10-27
卷号14期号:10页码:12679-12696
关键词hepatocellular carcinoma prussian blue photothermal therapy sorafenib hypoxia antiprogrammed death-ligand I immunotherapy
ISSN号1936-0851
DOI10.1021/acsnano.0c01453
通讯作者Du, Yang(yang.du@ia.ac.cn) ; Fang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Hepatocellular carcinoma (HCC) is a common and highly malignant tumor that is prone to recurrence and metastasis and has no effective treatment. Unsurprisingly, its prognosis is quite poor; early detection methods and effective low toxicity treatments are urgently needed. To achieve these goals, we designed a multifunctional, U.S. Food and Drug Administration-approved Prussian blue (PB) nanoparticle (NP) with a porous metal organic frame loaded with sorafenib l (SF), conjugated with HCC-specific targeting peptide SP94 and the near-infrared dye cyanine (Cy)S.S. These NPs are amenable to multimodal imaging for dynamic monitoring of their biodistribution and tumor-targeting effects. The SP94-PB-SF-Cy5.5 NPs achieved targeted delivery and controlled SF release and exhibited good photothermal effects. In this strategy, photothermal therapy and SF treatment complement each other, reducing the side effects of SF and achieving a therapeutic effect without local tumor recurrence. In addition, the catalase-like ability of l the NPs alleviates tumor hypoxia, and their photothermal effects l induce immunogenic cell death, leading to the release of tumor-associated antigens. These effects combine to trigger an antitumor immune response; the NPs also displayed promising inhibitory effects on tumor metastasis and recurrence and produced an abscopal effect and long-term immunological memory when combined with antiprogrammed death-ligand I (PD-LI) immunotherapy. These safe, multifunctional NPs represent a valuable treatment option for HCC. In addition, this next-generation treatment model may provide some ideas for the management of HCC and other cancers.
WOS关键词PRUSSIAN BLUE NANOPARTICLES ; CHECKPOINT BLOCKADE ; T-CELLS ; CANCER ; GENERATION ; IMMUNITY ; THERAPY ; SIGNALS
资助项目National Natural Science Foundation of China[81627805] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81822022] ; National Natural Science Foundation of China[81771846] ; National Key Research and Development Program of China[2 0 1 7YFAO 2 0 5 2 0 0] ; National Key Research and Development Program of China[2017YFA0700401] ; National Key Research and Development Program of China[2016YFA0100902] ; National Key Research and Development Program of China[2016YFC0106500] ; Science and Technology Plan Project of Guangzhou[201604020144] ; Science and Technology Plan Project of Guangzhou[201704020141] ; NSFC-GD Union Foundation[U1401254] ; Beijing Excellent Young Talents Training Support Program[2018000021223ZK48] ; Peking University Third Hospital[BYSYZD2019018] ; Peking University Third Hospital[jyzc2018-02] ; Peking University Third Hospital[BYSY2015023]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000586793400026
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; National Key Research and Development Program of China ; Science and Technology Plan Project of Guangzhou ; NSFC-GD Union Foundation ; Beijing Excellent Young Talents Training Support Program ; Peking University Third Hospital
源URL[http://ir.ia.ac.cn/handle/173211/42677]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Du, Yang; Fang, Chihua; Tian, Jie
作者单位1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
2.Peking Univ Third Hosp, Dept Ultrasound, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
4.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Peoples R China
5.Beijing Ctr Dis Control & Prevent, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Tianjun,Liang, Xiaolong,Wang, Peifeng,et al. A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence[J]. ACS NANO,2020,14(10):12679-12696.
APA Zhou, Tianjun.,Liang, Xiaolong.,Wang, Peifeng.,Hu, Yueyang.,Qi, Yafei.,...&Tian, Jie.(2020).A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence.ACS NANO,14(10),12679-12696.
MLA Zhou, Tianjun,et al."A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence".ACS NANO 14.10(2020):12679-12696.

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来源：自动化研究所

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