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Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats

文献类型：期刊论文

作者Wang, Wenzhu3,4; Liu, Xu5; Yang, Zhengyi1; Shen, Hui6; Liu, Lixu2,5; Yu, Yan3,4,7; Zhang, Tong1,3,4
刊名FRONTIERS IN NEUROSCIENCE
出版日期2020-11-30
卷号14页码:16
关键词levodopa hippocampus global cerebral ischemia reperfusion injury structural synaptic plasticity cognitive function
DOI10.3389/fnins.2020.586321
通讯作者Wang, Wenzhu(wzhwang11@163.com)
英文摘要The cognitive impairment caused by cerebral ischemia/reperfusion is an unsolved problem in the field of international neural rehabilitation. Not only ameliorates the consciousness level of certain patients who suffered from ischemia-reperfusion injury and were comatose for a long time period after cerebral resuscitation treatment, but levodopa also improves the symptoms of neurological deficits in rats with global cerebral ischemia-reperfusion injury. However, Levodopa has not been widely used as a brain protection drug after cardiopulmonary resuscitation, because of its unclear repair mechanism. Levodopa was used to study the neuroplasticity in the hippocampus of global cerebral ischemia/reperfusion injury rat model, established by Pulsinelli's four-vessel occlusion method. Levodopa was injected intraperitoneally at 50 mg/kg/d for 7 consecutive days after 1st day of surgery. The modified neurological function score, Morris water maze, magnetic resonance imaging, Nissl and TH staining, electron microscopy and western blot were used in the present study. The results showed that levodopa improved the neurological function and learning and memory of rats after global cerebral ischemia/reperfusion injury, improved the integrity of white matter, and density of gray matter in the hippocampus, increased the number of synapses, reduced the delayed neuronal death, and increased the expression of synaptic plasticity-related proteins (BDNF, TrkB, PSD95, and Drebrin) in the hippocampus. In conclusion, levodopa can improve cognitive function after global cerebral ischemia/reperfusion injury by enhancing the synaptic plasticity in the hippocampus.
WOS关键词HOSPITAL CARDIAC-ARREST ; DENDRITIC SPINE LOSS ; MOTOR RECOVERY ; HEART-DISEASE ; DOPAMINE ; STROKE ; MEMORY ; MATTER ; REPERFUSION ; DORSAL
资助项目Special Fund for the Fundamental Research Funds for Central Public Welfare Research Institutes[2018CZ-5] ; Special Fund for the Fundamental Research Funds for Central Public Welfare Research Institutes[2019CZ-7]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000598158900001
出版者FRONTIERS MEDIA SA
资助机构Special Fund for the Fundamental Research Funds for Central Public Welfare Research Institutes
源URL[http://ir.ia.ac.cn/handle/173211/42710]  
专题自动化研究所_脑网络组研究中心
通讯作者Wang, Wenzhu
作者单位1.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
2.Beijing Boai Hosp, China Rehabil Res Ctr, Beijing, Peoples R China
3.China Rehabil Sci Inst, Chinese Inst Rehabil Sci, Beijing, Peoples R China
4.China Rehabil Res Ctr, Beijing Key Lab Neural Injury & Rehabil, Beijing, Peoples R China
5.Capital Med Univ, Sch Rehabil Med, Beijing, Peoples R China
6.Tianjin Med Univ, Sch Biomed Engn, Tianjin, Peoples R China
7.Beijing Inst Brain Disorders, Ctr Neural Injury & Repair, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Wenzhu,Liu, Xu,Yang, Zhengyi,et al. Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats[J]. FRONTIERS IN NEUROSCIENCE,2020,14:16.
APA Wang, Wenzhu.,Liu, Xu.,Yang, Zhengyi.,Shen, Hui.,Liu, Lixu.,...&Zhang, Tong.(2020).Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats.FRONTIERS IN NEUROSCIENCE,14,16.
MLA Wang, Wenzhu,et al."Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats".FRONTIERS IN NEUROSCIENCE 14(2020):16.

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来源：自动化研究所

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