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Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer

文献类型：期刊论文

作者Guo, Pengyu1,2,3; Wang, Lu1,3; Shang, Wenting2; Chen, Jiuwei1,3; Chen, Ziyin1,3; Xiong, Feng1,3; Wang, Ziqi1,3; Tong, Zhichao1,3; Wang, Keliang1,3; Yang, Liming4
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2020-12-09
卷号12期号:49页码:54367-54377
关键词bladder cancer ferroptosis macrophage intravesical therapy PTT
ISSN号1944-8244
DOI10.1021/acsami.0c15176
通讯作者Tian, Jie(jie.tian@ia.ac.cn) ; Xu, Wanhai(xuwanhai@163.com)
英文摘要Bladder cancer displays multiple biological features aided in drug resistance; therefore, single therapy fails to induce complete tumor regression. To address this issue, various kinds of cell death of cancer cells as well as restoring tumor immune microenvironment need to be taken into consideration. Here, we introduce a gel system termed AuNRs&IONs@Gel, which target-delivers a combination of photothermal, ferroptotic, and immune therapy through intravesical instillation. AuNRs&IONs@Gel consists of a gel delivery platform, embedded gold nanorods (AuNRs), and iron oxide nanoparticles (IONs). The targeted delivery gel platform provides dextran aldehyde-selective adhesion with cancer collagen. In this condition, photothermal therapy can be performed by gold nanorods (AuNRs) under imaging-guided near-infrared radiation. Local high concentrations of IONs can be absorbed by cancer cell to induce ferroptosis. Moreover, tumor-associated macrophages which often display an immune-suppressive M2-like phenotype will be repolarized by IONs into the antitumor M1-like phenotype, exerting a direct antitumor effect and professional antigen presentation of dead cancer cells. This process triggers a potent immune response of innate and adapt immunities to protect tumor rechallenge in long terms. Our triple therapy strategy employs FDA-approved nanoparticles to inhibit bladder cancer which may possess great potential for clinical translation.
WOS关键词NANOMEDICINE
资助项目National Natural Science Foundation of China[81771898] ; National Natural Science Foundation of China[51903069] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HYDSYYXQN202001] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HY-DSYYXQN202003] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HYDSYYXQN202004] ; Fundamental Research Funds for the Provincial Universities[2019-KYYWF-0372] ; China Postdoctoral Science Foundation[2020M680047] ; Special project of Heilongjiang Postdoctoral Fund[LBH-TZ1017] ; Applied Technology Research and Development Project of Heilongjiang Province[GY2019YF0086]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000599505200009
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University ; Fundamental Research Funds for the Provincial Universities ; China Postdoctoral Science Foundation ; Special project of Heilongjiang Postdoctoral Fund ; Applied Technology Research and Development Project of Heilongjiang Province
源URL[http://ir.ia.ac.cn/handle/173211/42734]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian, Jie; Xu, Wanhai
作者单位1.Harbin Med Univ, Hosp 4, Urol Surg Dept, Heilongjiang Key Lab Sci Res Urol, Harbin 150081, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Inst Automat, Beijing 100190, Peoples R China
3.Harbin Med Univ, Hosp 4, NHC Key Lab Mol Probes & Targeted Diag & Therapy, Harbin 150081, Peoples R China
4.Harbin Med Univ, Dept Pathophysiol, Key Lab Cardiovasc Pathophysiol, Harbin 150081, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Pengyu,Wang, Lu,Shang, Wenting,et al. Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(49):54367-54377.
APA Guo, Pengyu.,Wang, Lu.,Shang, Wenting.,Chen, Jiuwei.,Chen, Ziyin.,...&Xu, Wanhai.(2020).Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer.ACS APPLIED MATERIALS & INTERFACES,12(49),54367-54377.
MLA Guo, Pengyu,et al."Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer".ACS APPLIED MATERIALS & INTERFACES 12.49(2020):54367-54377.

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来源：自动化研究所

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