中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Selective Participation of Single Cortical Neurons in Neuronal Avalanches

文献类型:期刊论文

作者Bellay, Timothy3,4; Shew, Woodrow L.3,5; Yu, Shan1,3; Falco-Walter, Jessica J.2,3; Plenz, Dietmar3
刊名FRONTIERS IN NEURAL CIRCUITS
出版日期2021-01-22
卷号14页码:18
关键词nonhuman primate rat prefrontal cortex primary motor cortex high-density microelectrode array local field potential whole-cell patch recording cell assemblies
DOI10.3389/fncir.2020.620052
通讯作者Plenz, Dietmar(plenzd@mail.nih.gov)
英文摘要Neuronal avalanches are scale-invariant neuronal population activity patterns in the cortex that emerge in vivo in the awake state and in vitro during balanced excitation and inhibition. Theory and experiments suggest that avalanches indicate a state of cortex that improves numerous aspects of information processing by allowing for the transient and selective formation of local as well as system-wide spanning neuronal groups. If avalanches are indeed involved with information processing, one might expect that single neurons would participate in avalanche patterns selectively. Alternatively, all neurons could participate proportionally to their own activity in each avalanche as would be expected for a population rate code. Distinguishing these hypotheses, however, has been difficult as robust avalanche analysis requires technically challenging measures of their intricate organization in space and time at the population level, while also recording sub- or suprathreshold activity from individual neurons with high temporal resolution. Here, we identify repeated avalanches in the ongoing local field potential (LFP) measured with high-density microelectrode arrays in the cortex of awake nonhuman primates and in acute cortex slices from young and adult rats. We studied extracellular unit firing in vivo and intracellular responses of pyramidal neurons in vitro. We found that single neurons participate selectively in specific LFP-based avalanche patterns. Furthermore, we show in vitro that manipulating the balance of excitation and inhibition abolishes this selectivity. Our results support the view that avalanches represent the selective, scale-invariant formation of neuronal groups in line with the idea of Hebbian cell assemblies underlying cortical information processing.
资助项目Division of the Intramural Research Program (DIRP) of the National Institute of Mental Health (NIMH)[ZIAMH002797]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000614749200001
出版者FRONTIERS MEDIA SA
资助机构Division of the Intramural Research Program (DIRP) of the National Institute of Mental Health (NIMH)
源URL[http://ir.ia.ac.cn/handle/173211/42858]  
专题自动化研究所_脑网络组研究中心
通讯作者Plenz, Dietmar
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
2.Stanford Univ, Dept Neurol, Palo Alto, CA 94304 USA
3.NIMH, Sect Crit Brain Dynam, NIH, Bethesda, MD 20892 USA
4.Brown Univ, Dept Neurosci, Providence, RI 02912 USA
5.Univ Arkansas, Dept Phys, Fayetteville, AR 72701 USA
推荐引用方式
GB/T 7714
Bellay, Timothy,Shew, Woodrow L.,Yu, Shan,et al. Selective Participation of Single Cortical Neurons in Neuronal Avalanches[J]. FRONTIERS IN NEURAL CIRCUITS,2021,14:18.
APA Bellay, Timothy,Shew, Woodrow L.,Yu, Shan,Falco-Walter, Jessica J.,&Plenz, Dietmar.(2021).Selective Participation of Single Cortical Neurons in Neuronal Avalanches.FRONTIERS IN NEURAL CIRCUITS,14,18.
MLA Bellay, Timothy,et al."Selective Participation of Single Cortical Neurons in Neuronal Avalanches".FRONTIERS IN NEURAL CIRCUITS 14(2021):18.

入库方式: OAI收割

来源:自动化研究所

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