High-Resolution pO(2) Imaging Improves Quantification of the Hypoxic Fraction in Tumors During Radiation Therapy
文献类型：期刊论文
| 作者 | Cao, Xu5,6; Allu, Srinivasa Rao7,8; Jiang, Shudong1,5; Gunn, Jason R.5; Yao, Cuiping5,9; Xin, Jing5,9; Bruza, Petr5; Gladstone, David J.1,2,5; Jarvis, Lesley A.1,2; Tian, Jie3,6
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| 刊名 | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
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| 出版日期 | 2021-02-01 |
| 卷号 | 109期号:2页码:603-613 |
| ISSN号 | 0360-3016 |
| DOI | 10.1016/j.ijrobp.2020.09.046 |
| 通讯作者 | Pogue, Brian W.(brian.w.pogue@dartmouth.edu) |
| 英文摘要 | Purpose: The extreme microscopic heterogeneity of tumors makes it difficult to characterize tumor hypoxia. We evaluated how changes in the spatial resolution of oxygen imaging could alter measures of tumor hypoxia and their correlation to radiation therapy response. Methods and Materials: Cherenkov-Excited Luminescence Imaging in combination with an oxygen probe, Oxyphor PtG4 was used to directly image tumor pO(2) distributions with 0.2 mm spatial resolution at the time of radiation delivery. These pO(2) images were analyzed with variations of reduced spatial resolution from 0.2 mm to 5 mm, to investigate the influence of how reduced imaging spatial resolution would affect the observed tumor hypoxia. As an in vivo validation test, mice bearing tumor xenografts were imaged for hypoxic fraction and median pO(2) to examine the predictive link with tumor response to radiation therapy, while accounting for spatial resolution. Results: In transitioning from voxel sizes of 200 mu m to 3 mm, the median pO(2) values increased by a few mm Hg, and the hypoxic fraction decreased by more than 50%. When looking at radiation-responsive tumors, the median pO(2) values changed just a few mm Hg as a result of treatment, and the hypoxic fractions changed by as much as 50%. This latter change, however, could only be seen when sampling was performed with high spatial resolution. Median pO(2) or similar quantities obtained from low resolution measurements are commonly used in clinical practice, however these parameters are much less sensitive to changes in the tumor microenvironment than the tumor hypoxic fraction obtained from high-resolution oxygen images. Conclusions: This study supports the hypothesis that for adequate measurements of the tumor response to radiation therapy, oxygen imaging with high spatial resolution is required to accurately characterize the hypoxic fraction. (C) 2020 Elsevier Inc. All rights reserved. |
| WOS关键词 | HYPERBARIC-OXYGEN ; NECK-CANCER ; PET ; RADIOTHERAPY ; HEAD ; IMPACT ; PHOSPHORESCENCE ; OPPORTUNITIES ; ARABINOSIDE ; MICROPET |
| 资助项目 | National Institutes of Health[R01 EB024498] ; National Institutes of Health[U24 EB028941] ; National Institutes of Health[R21 EB027397] ; [P30 CA023108] |
| WOS研究方向 | Oncology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000607368300034 |
| 资助机构 | National Institutes of Health |
| 源URL | [http://ir.ia.ac.cn/handle/173211/42900]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Pogue, Brian W. |
| 作者单位 | 1.Dartmouth Hitchcock Med Ctr, Norris Cotton Canc Ctr, Lebanon, NH 03766 USA 2.Dartmouth Coll, Geisel Sch Med, Dept Med, Hanover, NH USA 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China 4.Dartmouth Coll, Geisel Sch Med, Dept Radiol, Hanover, NH USA 5.Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA 6.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol Neuroimaging, Minist Educ, Xian, Shaanxi, Peoples R China 7.Univ Penn, Dept Biochem & Biophys, Perelman Sch Med, Philadelphia, PA 19104 USA 8.Univ Penn, Dept Chem, Sch Arts & Sci, Philadelphia, PA 19104 USA 9.Xi An Jiao Tong Univ, Inst Biomed Analyt Technol & Instrumentat, Sch Life Sci & Technol, Key Lab Biomed Informat Engn,Minist Educ, Xian, Shaanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Xu,Allu, Srinivasa Rao,Jiang, Shudong,et al. High-Resolution pO(2) Imaging Improves Quantification of the Hypoxic Fraction in Tumors During Radiation Therapy[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2021,109(2):603-613. |
| APA | Cao, Xu.,Allu, Srinivasa Rao.,Jiang, Shudong.,Gunn, Jason R..,Yao, Cuiping.,...&Pogue, Brian W..(2021).High-Resolution pO(2) Imaging Improves Quantification of the Hypoxic Fraction in Tumors During Radiation Therapy.INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,109(2),603-613. |
| MLA | Cao, Xu,et al."High-Resolution pO(2) Imaging Improves Quantification of the Hypoxic Fraction in Tumors During Radiation Therapy".INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 109.2(2021):603-613. |
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