Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics
文献类型：期刊论文
| 作者 | Jin, Yushen1,4 ; Tang, Chu2; Tian, Jie3; Shao, Bing1,4
|
| 刊名 | BIOCONJUGATE CHEMISTRY
 |
| 出版日期 | 2021-01-20 |
| 卷号 | 32期号:1页码:161-171 |
| ISSN号 | 1043-1802 |
| DOI | 10.1021/acs.bioconjchem.0c00594 |
| 通讯作者 | Tian, Jie(jie.tian@ia.ac.cn) ; Shao, Bing(shaobingch@sina.com) |
| 英文摘要 | Early identification and treatment of breast cancer is very important for breast conserving therapy and to improve the prognosis and survival rates of patients. Multifunctional nanotheranostic agents are of particular importance in the field of precise nanomedicine, since they can augment the visualization and treatment of cancer. We developed a novel Bi2S3 nanoparticle coated with a hyaluronic acid (HA)-modified tantalum oxide (TaOx) nanoshell (Bi2S3@TaOx-HA). The as-prepared core/shell nanoparticles exhibited a high BO, nanoparticle loading efficiency of (67 wt %). The TaOx nanoshell exhibited excellent biocompatibility and computed tomography imaging capacity, and the Bi2S3 nanoparticles exhibited an excellent photothermal transducing performance and computed tomography (CT) and photoacoustic imaging capacity. As a result of these merits, the Bi2S3@TaOx core-shell nanoparticles can act as a theranostic agent for CT/photoacoustically monitored enhanced photothermal therapy. These findings will evoke new interest in future cancer therapeutic strategies based on biocompatible functional nanomaterials. |
| WOS关键词 | PHOTOTHERMAL THERAPY ; DRUG-RELEASE ; NANOPARTICLES ; OXIDE ; CHEMOTHERAPY ; AGENTS |
| 资助项目 | National Key Research and Development Program of China[2019YFC1604600] ; National Natural Science Foundation of China[82072098] ; National Natural Science Foundation of China[81701771] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000612551500017 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.ia.ac.cn/handle/173211/43243]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Tian, Jie; Shao, Bing |
| 作者单位 | 1.Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China 2.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian 710126, Shaanxi, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.Beijing Ctr Dis Prevent Med Res, Cent Res Lab, Beijing 100013, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Yushen,Tang, Chu,Tian, Jie,et al. Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics[J]. BIOCONJUGATE CHEMISTRY,2021,32(1):161-171. |
| APA | Jin, Yushen,Tang, Chu,Tian, Jie,&Shao, Bing.(2021).Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics.BIOCONJUGATE CHEMISTRY,32(1),161-171. |
| MLA | Jin, Yushen,et al."Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics".BIOCONJUGATE CHEMISTRY 32.1(2021):161-171. |
入库方式： OAI收割
来源：自动化研究所
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