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Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging

文献类型：期刊论文

作者Chen, Hao5; Shou, Kangquan2,6; Chen, Si2,6; Qu, Chunrong5; Wang, Zhiming5; Jiang, Lei2,6; Zhu, Mark2,6; Ding, Bingbing2,6; Qian, Kun2,6; Ji, Aiyan5
刊名ADVANCED MATERIALS
出版日期2021-03-12
页码13
关键词fluorescence‐ imaging‐ guided tumor surgery NIR‐ II fluorescence imaging pH‐ responsive materials self‐ assembly tumor imaging
ISSN号0935-9648
DOI10.1002/adma.202006902
通讯作者Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Cheng, Zhen(zcheng@stanford.edu)
英文摘要Development of novel nanomaterials for disease theranostics represents an important direction in chemistry and precision medicine. Fluorescent molecular probes in the second near-infrared window (NIR-II, 1000-1700 nm) show high promise because of their exceptional high detection sensitivity, resolution, and deep imaging depth. Here, a sharp pH-sensitive self-assembling cyclopeptide-dye, SIMM1000, as a smart nanoprobe for NIR-II imaging of diseases in living animals, is reported. This small molecule assembled nanoprobe exhibits smart properties by responding to a sharp decrease of pH in the tumor microenvironment (pH 7.0 to 6.8), aggregating from small nanoprobe (80 nm at pH 7.0) into large nanoparticles (>500 nm at pH 6.8) with approximate to 20-30 times enhanced fluorescence compared with the non-self-assembled CH-4T. It yields micrometer-scale resolution in blood vessel imaging and high contrast and resolution in bone and tumor imaging in mice. Because of its self-aggregation in acidic tumor microenvironments in situ, SIMM1000 exhibits high tumor accumulation and extremely long tumor retention (>19 days), while being excretable from normal tissues and safe. This smart self-assembling small molecule strategy can shift the paradigm of designing new nanomaterials for molecular imaging and drug development.
资助项目Office of Science (BER), U.S. Department of Energy[DE-SC0008397] ; Center for Cancer Nanotechnology Excellence for Translational Diagnostics (CCNE-TD)[U54 CA151459] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[61622117] ; National Natural Science Foundation of China[82071976] ; Shanghai Pujiang Program[19PJ1411100] ; Shanghai Municipal Science and Technology Major Project
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000627811500001
出版者WILEY-V C H VERLAG GMBH
资助机构Office of Science (BER), U.S. Department of Energy ; Center for Cancer Nanotechnology Excellence for Translational Diagnostics (CCNE-TD) ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Shanghai Pujiang Program ; Shanghai Municipal Science and Technology Major Project
源URL[http://ir.ia.ac.cn/handle/173211/43327]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Hu, Zhenhua; Tian, Jie; Cheng, Zhen
作者单位1.Stanford Univ, Sch Med, Div Oncol, Dept Pathol, Stanford, CA 94305 USA
2.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Dept Radiol, Stanford, CA 94305 USA
3.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing Key Lab Mol Imaging, CAS Key Lab Mol Imaging,Inst Automat, Beijing 100190, Peoples R China
4.Stanford Univ, Sch Med, Div Oncol, Dept Med, Stanford, CA 94305 USA
5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Mol Imaging Res, Shanghai 201203, Peoples R China
6.Stanford Univ, Canary Ctr Stanford Canc Early Detect, BioX Program, Mol Imaging Program Stanford MIPS, Stanford, CA 94305 USA
推荐引用方式
GB/T 7714		 Chen, Hao,Shou, Kangquan,Chen, Si,et al. Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging[J]. ADVANCED MATERIALS,2021:13.
APA Chen, Hao.,Shou, Kangquan.,Chen, Si.,Qu, Chunrong.,Wang, Zhiming.,...&Cheng, Zhen.(2021).Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging.ADVANCED MATERIALS,13.
MLA Chen, Hao,et al."Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging".ADVANCED MATERIALS (2021):13.

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来源：自动化研究所

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