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Inhibition-directed multimodal imaging fusion patterns in adults with ADHD and its potential underlying "gene-brain-cognition" relationship

文献类型：期刊论文

作者Guo, Xiaojie1,4,5; Liu, Lu1,4,5; Li, Tiantian2,3,8; Zhao, Qihua1,4,5; Li, Hui1,4,5; Huang, Fang1,4,5; Wang, Yanfei1,4,5; Qian, Qiujin1,4,5; Cao, Qingjiu1,4,5; Wang, Yufeng1,4,5
刊名CNS NEUROSCIENCE & THERAPEUTICS
出版日期2021-03-16
页码10
ISSN号1755-5930
关键词adults with attention-deficit/hyperactivity disorder inhibition multimodal MRI fusion NOS1 ex1f-VNTR
DOI10.1111/cns.13625
通讯作者Sui, Jing(kittysj@gmail.com) ; Sun, Li(sunlioh@bjmu.edu.cn)
英文摘要Aims: Inhibition deficits have been suggested to be a core cognitive impairment in attention-deficit/hyperactivity disorder (ADHD). Exploring imaging patterns and the potential genetic components associated with inhibition deficits would definitely promote our understanding of the neuropathological mechanism of ADHD. This study aims to investigate the multimodal imaging fusion features related to inhibition deficits in adults with ADHD (aADHD) and to make an exploratory analysis of the role of inhibition-related gene, NOS1, on those brain alterations. Methods: Specifically, multisite canonical correlation analysis with reference plus joint independent component analysis (MCCAR + jICA) was conducted to identify the joint co-varying gray matter volume (GMV) and the functional connectivity (FC) features related to inhibition in 69 aADHD and 44 healthy controls. Then, mediation analysis was employed to detect the relationship among inhibition-related imaging features, NOS1 ex1f-VNTR genotypes, and inhibition. Results: Inhibition-directed multimodal imaging fusion patterns of aADHD were reduced GMV and FC in inhibition network and increased GMV and FC in default mode network. The results showed a significant indirect effect of NOS1 ex1f-VNTR on inhibition via FC component [effect size = -0.54 (SE = 0.29), 95% CI = -1.16 to -0.01]. In addition, the results indicated a significant indirect effect of GMV on the inhibition via FC component [effect size = 0.43 (SE = 0.23), 95% CI = 0.12 to 1.00]. Conclusion: The findings suggested that reduced GMV and FC in inhibition network and increased GMV and FC in default mode network were jointly responsible for inhibition deficits in aADHD. Both the NOS1 ex1f-VNTR genotypes and GMV might influence the inhibition through the mediation effect of the aforementioned FC (NOS1/GMV(-> FC ->)Inhibition).
资助项目National Natural Sciences Foundation of China[81771479] ; National Natural Sciences Foundation of China[81971284] ; National Natural Sciences Foundation of China[81873802] ; National Natural Sciences Foundation of China[81471382] ; National Natural Sciences Foundation of China[61773380] ; Beijing Municipal Science and Technology Program[Z181100001518005] ; Beijing Municipal Science and Technology Program[Z171100001017089] ; Beijing Municipal Science and Technology Program[Z171100000117004] ; Beijing Natural Science Foundation[7172245] ; Sanming Project of Medicine in Shenzhen The ADHD research group from Peking University Sixth Hospital[SZSM201612036]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy
语种英语
出版者WILEY
WOS记录号WOS:000629303800001
资助机构National Natural Sciences Foundation of China ; Beijing Municipal Science and Technology Program ; Beijing Natural Science Foundation ; Sanming Project of Medicine in Shenzhen The ADHD research group from Peking University Sixth Hospital
源URL[http://ir.ia.ac.cn/handle/173211/44067]  
专题自动化研究所_脑网络组研究中心
通讯作者Sui, Jing; Sun, Li
作者单位1.Peking Univ, Minist Hlth, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
4.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
5.Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China
7.Emory Univ, Georgia Inst Technol, Georgia State Univ, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30322 USA
8.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Xiaojie,Liu, Lu,Li, Tiantian,et al. Inhibition-directed multimodal imaging fusion patterns in adults with ADHD and its potential underlying "gene-brain-cognition" relationship[J]. CNS NEUROSCIENCE & THERAPEUTICS,2021:10.
APA Guo, Xiaojie.,Liu, Lu.,Li, Tiantian.,Zhao, Qihua.,Li, Hui.,...&Sun, Li.(2021).Inhibition-directed multimodal imaging fusion patterns in adults with ADHD and its potential underlying "gene-brain-cognition" relationship.CNS NEUROSCIENCE & THERAPEUTICS,10.
MLA Guo, Xiaojie,et al."Inhibition-directed multimodal imaging fusion patterns in adults with ADHD and its potential underlying "gene-brain-cognition" relationship".CNS NEUROSCIENCE & THERAPEUTICS (2021):10.

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