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Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging

文献类型：期刊论文

作者Jiang, Zhenqi3,5; Han, Xiao4,5; Du, Yang2,4; Li, Yanying1,2,3; Li, Yong3; Li, Juan1,3; Tian, Jie4,6; Wu, Aiguo1,3
刊名NANO LETTERS
出版日期2021-04-14
卷号21期号:7页码:2730-2737
关键词Magnetic Particle Imaging Metal-Organic Frameworks High-Temperature Pyrolysis Esophageal Squamous Cell Cancer
ISSN号1530-6984
DOI10.1021/acs.nanolett.0c04455
通讯作者Li, Juan(lij@nimte.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Wu, Aiguo(aiguo@nimte.ac.cn)
英文摘要Recently, magnetic particle imaging (MPI) has shown diverse biomedical applications such as cell tracking, lung perfusion, image-guided hyperthermia, and so forth. However, the currently reported MPI agents cannot achieve the possible theoretical detection limit of MPI (20 nM). A previous theoretical study has shown that the MPI performance of superparamagnetic iron oxide nanoparticles (SPIONs) can be enhanced by carbon supporting and metal doping. In the current study, a series of mixed metal metal-organic framework-derived carbon supporting SPIONs were synthesized by pyrolysis. Among the synthesized SPIONs, the MPI signal intensity of ZnFe2O4/C@PDA was found to be 4.7 times higher than the commercial MPI contrast (Vivotrax) having the same Fe concentration. ZnFe2O4/C@PDA also showed the highest MPI intensity in tumor-bearing-mice among all tested samples. Furthermore, they were found highly biocompatible and showed linear cell quantification. This work can open new avenues for the design and development of novel and high-performance MPI agents.
WOS关键词FAVORABLE BIOCOMPATIBILITY ; NANOPARTICLES ; ACCUMULATION
资助项目National Natural Science Foundation of China[81871411] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[32011530115] ; National Natural Science Foundation of China[32025021] ; Key R&D Program of Zhejiang Province[2020C03110] ; Youth Innovation Promotion Association Foundation of CAS[2017340] ; National Key R&D Program of China[2018YFC0910601] ; Beijing Natural Science Foundation[7212207] ; China Postdoctoral Science Foundation[2020M680395]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000641160500004
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; Key R&D Program of Zhejiang Province ; Youth Innovation Promotion Association Foundation of CAS ; National Key R&D Program of China ; Beijing Natural Science Foundation ; China Postdoctoral Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/44482]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Li, Juan; Tian, Jie; Wu, Aiguo
作者单位1.Adv Energy Sci & Technol Guangdong Lab, Huizhou 516003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn,CAS Key Lab Magnet, Ningbo 315201, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
5.Beijing Inst Technol, Inst Engn Med, Sch Life Sci, Beijing 100081, Peoples R China
6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Zhenqi,Han, Xiao,Du, Yang,et al. Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging[J]. NANO LETTERS,2021,21(7):2730-2737.
APA Jiang, Zhenqi.,Han, Xiao.,Du, Yang.,Li, Yanying.,Li, Yong.,...&Wu, Aiguo.(2021).Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging.NANO LETTERS,21(7),2730-2737.
MLA Jiang, Zhenqi,et al."Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging".NANO LETTERS 21.7(2021):2730-2737.

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来源：自动化研究所

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