mainly relies on hospital examination and treatment, which are complicated and untimely. The emerging of mobile devices provides the possibility to manage people’s health status in a convenient and instant way. Estimation of health status can be achieved with various kinds of data streams continuously collected from wearable sensors. However, these data streams are multi-source and heterogeneous, containing complex temporal structures with local contextual and global temporal aspects, which makes the feature learning and data joint utilization challenging. We propose to model the behavior-related multi-source data streams with a localglobal graph, which contains multiple local context sub-graphs to learn short term local context information with heterogeneous graph neural networks and a global temporal sub-graph to learn long term dependency with self-attention networks. Then health status is predicted based on the structure-aware representation learned from the local-global behavior graph. We take experiments on StudentLife dataset, and extensive results demonstrate the effectiveness of our proposed model.