Growth inhibition of breast cancer in rat by AAV mediated angiostatin gene
文献类型：期刊论文
| 作者 | Li Ran; Chen Hong; Ren Changshan |
| 刊名 | CHINESE JOURNAL OF CANCER RESEARCH
 |
| 出版日期 | 2007 |
| 卷号 | 19期号:2页码:108-112 |
| 关键词 | ANGIOGENESIS MECHANISMS AAV-ANG breast cancer growth inhibition microvessel density |
| ISSN号 | 1000-9604 |
| 其他题名 | Growth Inhibition of Breast Cancer in Rat by AAV Mediated Angiostatin Gene |
| 英文摘要 | Objective: To observe growth inhibition effect of adeno-associated viral vectors (AAV) mediated angiostatin (ANG) gene on implanted breast cancer in rat and its mechanism. Methods: Gene transfer technique was used to transfer AAV-ANG to the tumor. Growth curves were drawn to observe the growth of breast cancer implanted in rat, and immunohistochemical method was used to detect the effects of angiostatin on microvesel density (MVD) of breast cancer implanted in rat. Results: Angiostatin inhibited the growth of breast cancer implanted in rat and decreased the microvessel density of tumor. Conclusion: Expression of an angiostatin transgene can suppress the growth of breast cancer implanted in rat through the inhibition of the growth of microvessels, surggesting that angiostatin gene transfer technique may be effective against breast cancer. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:2911737 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/87686]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Li Ran,Chen Hong,Ren Changshan. Growth inhibition of breast cancer in rat by AAV mediated angiostatin gene[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(2):108-112. |
| APA | Li Ran,Chen Hong,&Ren Changshan.(2007).Growth inhibition of breast cancer in rat by AAV mediated angiostatin gene.CHINESE JOURNAL OF CANCER RESEARCH,19(2),108-112. |
| MLA | Li Ran,et al."Growth inhibition of breast cancer in rat by AAV mediated angiostatin gene".CHINESE JOURNAL OF CANCER RESEARCH 19.2(2007):108-112. |
入库方式： OAI收割
来源：金属研究所
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