Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves
文献类型：期刊论文
| 作者 | Li, Bo-han1,4; Yang, Ke2; Wang, Xiao3 |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2016-12-01 |
| 卷号 | 11期号:12页码:2012-2017 |
| 关键词 | nerve regeneration peripheral nerve regeneration biodegradable magnesium wire sciatic nerve rats nerve growth factor P75 neurotrophin receptor tyrosine receptor kinase A neural regeneration |
| ISSN号 | 1673-5374 |
| DOI | 10.4103/1673-5374.197146 |
| 通讯作者 | Wang, Xiao(bysywangxiao@163.com) |
| 英文摘要 | Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve regeneration. A rat acute sciatic nerve compression model was made, and AZ31 Mg wire (3 mm diameter; 8 mm length) bridged at both ends of the nerve. Our results demonstrate that sciatic functional index, nerve growth factor, p75 neurotrophin receptor, and tyrosine receptor kinase A mRNA expression are increased by Mg wire in Mg model. The numbers of cross section nerve fibers and regenerating axons were also increased. Sciatic nerve function was improved and the myelinated axon number was increased in injured sciatic nerve following Mg treatment. Immunofluorescence histopathology showed that there were increased vigorous axonal regeneration and myelin sheath coverage in injured sciatic nerve after Mg treatment. Our findings confirm that biodegradable Mg wire can promote the regeneration of acute compressed sciatic nerves. |
| 资助项目 | National Natural Science Foundation of China[81400528] ; China Postdoctoral Science Foundation[20130390827] |
| WOS研究方向 | Cell Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000393890900029 |
| 出版者 | MEDKNOW PUBLICATIONS & MEDIA PVT LTD |
| 资助机构 | National Natural Science Foundation of China ; China Postdoctoral Science Foundation |
| 源URL | [http://ir.imr.ac.cn/handle/321006/123758]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Wang, Xiao |
| 作者单位 | 1.Binzhou Med Univ, Dept Oral Maxillofacial Surg, Yantai, Shandong, Peoples R China 2.Chinese Acad Sci, Met Res Inst, Shenyang, Liaoning Provin, Peoples R China 3.Peking Univ, Hosp 3, Dept Oral & Maxillofacial Surg, Beijing, Peoples R China 4.Gen Hosp Peoples Liberat Army, Dept Oral Maxillofacial Surg, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Bo-han,Yang, Ke,Wang, Xiao. Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves[J]. NEURAL REGENERATION RESEARCH,2016,11(12):2012-2017. |
| APA | Li, Bo-han,Yang, Ke,&Wang, Xiao.(2016).Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves.NEURAL REGENERATION RESEARCH,11(12),2012-2017. |
| MLA | Li, Bo-han,et al."Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves".NEURAL REGENERATION RESEARCH 11.12(2016):2012-2017. |
入库方式： OAI收割
来源：金属研究所
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