Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes
文献类型：期刊论文
| 作者 | Dong Jiahui1,2; Tan Lili1; Yang Ke1 |
| 刊名 | ACTA METALLURGICA SINICA
 |
| 出版日期 | 2017-10-11 |
| 卷号 | 53期号:10页码:1197-1206 |
| ISSN号 | 0412-1961 |
| 关键词 | bone defect bone repair osteogenesis Mg-based metal biodegradable |
| DOI | 10.11900/0412.1961.2017.00279 |
| 通讯作者 | Yang Ke(kyang@imr.ac.cn) |
| 英文摘要 | Bone defects are very challenging in orthopedic practice due to a variety of reasons. Bone repair requires four critical elements, biocompatibility, osteoconduction, osteoinduction and osteogenesis. The autografts still exist some problems for applications such as the limitation of available autogenous bones and post-operative complications, although they are considered as the "gold standard" in bony defect repairs. Generally the synthetic bone substitutes do not possess osteoinductive and osteogenic activities. Therefore, the clinical bone grafts and bone-graft substitutes have their own shortcomings in the repair of bone defects. Biodegradable magnesium-based metals, including pure magnesium and magnesium alloys, have been concerned and studied recently due to their biodegradation, good biocompatibility and similar elastic modulus and density with bone tissue. This paper summarizes the biological behavior of magnesium-based metals for bone defects repair application, including ability of promoting osteogenesis, osteoconduction and potential osteoinduction, as well as some particular biofunctions such as antibacterial and antitumor properties. The great advantages and potentials of magnesium in bone defects repair can not be denied as a promising class of bone substitutes, although further researches are still needed for clinical applications. |
| 资助项目 | National Natural Science Foundation of China[81401773] ; National Natural Science Foundation of China[31500777] |
| WOS研究方向 | Metallurgy & Metallurgical Engineering |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:000416301400005 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.imr.ac.cn/handle/321006/125458]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Yang Ke |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong Jiahui,Tan Lili,Yang Ke. Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes[J]. ACTA METALLURGICA SINICA,2017,53(10):1197-1206. |
| APA | Dong Jiahui,Tan Lili,&Yang Ke.(2017).Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes.ACTA METALLURGICA SINICA,53(10),1197-1206. |
| MLA | Dong Jiahui,et al."Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes".ACTA METALLURGICA SINICA 53.10(2017):1197-1206. |
入库方式： OAI收割
来源：金属研究所
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