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Role of placenta-specific protein 1 in trophoblast invasion and migration

文献类型：期刊论文

作者Chang, Wen-Lin1,2; Yang, Qing1; Zhang, Hui; Lin, Hai-Yan2,3; Zhou, Zhi2,4; Lu, Xiaoyin2,4; Zhu, Cheng2; Xue, Li-Qun1; Wang, Hongmei2
刊名REPRODUCTION
出版日期2014-10-01
卷号148期号:4页码:343-352
ISSN号1470-1626
DOI10.1530/REP-14-0052
通讯作者Wang, Hongmei(wanghm@ioz.ac.cn)
英文摘要Placenta-specific protein 1 (PLAC1), a placenta-specific gene, is known to be involved in the development of placenta in both humans and mice. However, the precise role of PLAC1 in placental trophoblast function remains unclear. In this study, the localization of PLAC1 in human placental tissues and its physiological significance in trophoblast invasion and migration are investigated by technical studies including real-time RT-PCR, in situ hybridization, immunohistochemistry, and functional studies by utilizing cell invasion and migration assays in the trophoblast cell line HTR8/SVneo as well as the primary inducing extravillous trophoblasts (EVTs). The results show that PLAC1 is mainly detected in the trophoblast columns and syncytiotrophoblast of the first-trimester human placental villi, as well as in the EVTs that invade into the maternal decidua. Knockdown of PLAC1 by RNA interference significantly suppresses the invasion and migration of HTR8/SVneo cells and shortens the distance of the outgrowth of the induced EVTs from the cytotrophoblast column of the explants. All the above data suggests that PLAC1 plays an important role in human placental trophoblast invasion and migration.
资助项目National Key Basic Research Program of China[2011CB944400] ; National Key Basic Research Program of China[2012CB126310] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDA01020102] ; Natural Science Foundation of China[81225004] ; Natural Science Foundation of China[31271603] ; Natural Science Foundation of China[31171438]
WOS研究方向Developmental Biology ; Reproductive Biology
语种英语
WOS记录号WOS:000343331100004
出版者BIOSCIENTIFICA LTD
资助机构National Key Basic Research Program of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Natural Science Foundation of China
源URL[http://ir.imr.ac.cn/handle/321006/125868]  
专题金属研究所_中国科学院金属研究所
通讯作者Wang, Hongmei
作者单位1.Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China
3.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing 100069, Peoples R China
4.Grad Sch Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Chang, Wen-Lin,Yang, Qing,Zhang, Hui,et al. Role of placenta-specific protein 1 in trophoblast invasion and migration[J]. REPRODUCTION,2014,148(4):343-352.
APA Chang, Wen-Lin.,Yang, Qing.,Zhang, Hui.,Lin, Hai-Yan.,Zhou, Zhi.,...&Wang, Hongmei.(2014).Role of placenta-specific protein 1 in trophoblast invasion and migration.REPRODUCTION,148(4),343-352.
MLA Chang, Wen-Lin,et al."Role of placenta-specific protein 1 in trophoblast invasion and migration".REPRODUCTION 148.4(2014):343-352.

入库方式： OAI收割

来源：金属研究所

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